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P-gp-IN-31

P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC50 values of 0.42 μM for KB cells and 0.43 μM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies.

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  • 화학식: C16H11F2NO3
  • 분자량:303.26
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • P-gp-IN-31 Chemical Structure
    P-gp-IN-31 Chemical Structure
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  • P-gp-IN-31 Chemical Structure
    P-gp-IN-31 Chemical Structure
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  • P-gp-IN-31