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Cat. No.: HY-153513

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PHD-1-IN-4

고객리뷰

Based on 1 Customer Validation

PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC₅₀ of 0.074 μM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.94%
CAS No.: 2009343-19-3
화학식: C₁₄H₁₀N₄
분자량:234.26

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

PHD-1-IN-4 Chemical Structure

CAS No.: 2009343-19-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC₅₀ of 0.074 μM^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

PHD-1-IN-4 (Compound 39) potently inhibits purified PHD-1 enzyme with an IC₅₀ of 0.074 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	AUC	C_max	F	B/P
Mice^[1]	3 mg/kg	p.o.	/	1869 ng·h/mL	5.58 μM	100 %	0.88
Mice^[1]	0.5 mg/kg	i.v.	31.6 mL/min/kg	/	/	/	/

Chemical Information

CAS No. 2009343-19-3
Appearance Solid
분자량 234.26
화학식 C₁₄H₁₀N₄
Color White to off-white
SMILES

N#CC=1C=CC(C2=CC=CC3=NC=NN32)=C(C1)C
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (213.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.2688 mL

21.3438 mL

42.6876 mL

5 mM

0.8538 mL

4.2688 mL

8.5375 mL

10 mM

0.4269 mL

2.1344 mL

4.2688 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.2688 mL	21.3438 mL	42.6876 mL	106.7190 mL
	5 mM	0.8538 mL	4.2688 mL	8.5375 mL	21.3438 mL
	10 mM	0.4269 mL	2.1344 mL	4.2688 mL	10.6719 mL
	15 mM	0.2846 mL	1.4229 mL	2.8458 mL	7.1146 mL
	20 mM	0.2134 mL	1.0672 mL	2.1344 mL	5.3360 mL
	25 mM	0.1708 mL	0.8538 mL	1.7075 mL	4.2688 mL
	30 mM	0.1423 mL	0.7115 mL	1.4229 mL	3.5573 mL
	40 mM	0.1067 mL	0.5336 mL	1.0672 mL	2.6680 mL
	50 mM	0.0854 mL	0.4269 mL	0.8538 mL	2.1344 mL
	60 mM	0.0711 mL	0.3557 mL	0.7115 mL	1.7787 mL
	80 mM	0.0534 mL	0.2668 mL	0.5336 mL	1.3340 mL
	100 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL

Keywords

MOQ

Minimum order quantity

100 mg

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견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
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PHD-1-IN-4

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Cancer Stem Cells Compound Library

Metabolic Enzyme Compound Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

PHD-1-IN-4

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Cancer Stem Cells Compound Library

Metabolic Enzyme Compound Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

PHD-1-IN-4 Related Classifications

HY-153513 Related Classifications