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Cat. No.: HY-125845B

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(S,S,S)-AHPC

(Synonyms: (S,S,S)-VH032-NH2)

(S,S,S)-AHPC ((S,S,S)-VH032-NH2) is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC (Compound 27) is a ligand used as a negative control for (S,R,S)-AHPC (HY-125845). (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein.

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CAS No.: 1797406-78-0
화학식: C₂₂H₃₀N₄O₃S
분자량:430.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(S,S,S)-AHPC Chemical Structure

CAS No.: 1797406-78-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
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Calculators
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

VHL

All Ligands for E3 Ligase Isoforms :

In Vitro

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1797406-78-0
분자량 430.56
화학식 C₂₂H₃₀N₄O₃S
SMILES

O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@H](C3)O)C([C@H](C(C)(C)C)N)=O
Synonyms

(S,S,S)-VH032-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Haag A, et al. Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. J Med Chem. 2025 Jan 9;68(1):506-530. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
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(S,S,S)-AHPC

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(S,S,S)-AHPC Related Classifications

HY-125845B Related Classifications