36 Results for "

Dimethylaminomicheliolide

" in MedChemExpress (MCE) Product Catalog:
Products (36)

36 Results for "Dimethylaminomicheliolide" in MCE Product Catalog:

4
CCZ01048 TFA
CCZ01048 TFA
0 Images
4 Cited Publications
Cat. No.: HY-P2336A
Target:  

Melanocortin Receptor

연구분야:  

Cancer

CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
1
Polymyxin B1
Polymyxin B1
0 Images
1 Cited Publications
Cat. No.: HY-A0248A
CAS No.: 4135-11-9
Category:  

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:  

Bacterial

Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .
1
Didemnin B
Didemnin B
0 Images
1 Cited Publications
Cat. No.: HY-105055
CAS No.: 77327-05-0
Purity:  99.95%
Category:  

Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer

Target:  

Others

Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .
1
Astressin 2B
Astressin 2B
0 Images
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:  

CRFR

연구분야:  

Neurological Disease Inflammation/Immunology

Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
1
Astressin 2B TFA
Astressin 2B TFA
0 Images
1 Cited Publications
Cat. No.: HY-P1108A
Target:  

CRFR

연구분야:  

Neurological Disease Inflammation/Immunology

Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
Glutathione ethyl ester
Glutathione ethyl ester
0 Images
Cat. No.: HY-134124
CAS No.: 92614-59-0
Purity:  95.8%
Target:  

Reactive Oxygen Species (ROS)

연구분야:  

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
Rusfertide
Rusfertide
0 Images
Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
Target:  

Ferroportin

연구분야:  

Others

Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
Insulin icodec
Insulin icodec
0 Images
Cat. No.: HY-P4070
CAS No.: 1188379-43-2
Target:  

Insulin Receptor

연구분야:  

Metabolic Disease

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
NODAGA-LM3
NODAGA-LM3
0 Images
Cat. No.: HY-P5362
Target:  

Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor

연구분야:  

Neurological Disease Cancer

NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .
Argifin
Argifin
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Cat. No.: HY-P2274
CAS No.: 243975-37-3
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

Parasite

Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .
ZP3022
ZP3022
0 Images
Cat. No.: HY-P10341
CAS No.: 1345835-12-2
Target:  

GCGR

연구분야:  

Metabolic Disease

ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .
MMP-2/MMP-9 Substrate
MMP-2/MMP-9 Substrate
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Cat. No.: HY-P10143
CAS No.: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Target:  

MMP

연구분야:  

Others

MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .
Polymyxin B1-d7 TFA
Polymyxin B1-d7 TFA
0 Images
Cat. No.: HY-A0248AS
Category:  

Microorganisms Antibiotics Disease Research Antibacterial Other Antibiotics

Target:  

Isotope-Labeled Compounds Bacterial

Polymyxin B1-d7 TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .
Noraramtide
Noraramtide
0 Images
Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Target:  

CD38 IFNAR

연구분야:  

Cancer

Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma .
SKF 100398
SKF 100398
0 Images
Cat. No.: HY-P3066
CAS No.: 77453-01-1
Synonyms: d(CH2)5Tyr(Et)VAVP
Target:  

Vasopressin Receptor

연구분야:  

Metabolic Disease

SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .
MAPI
MAPI
0 Images
Cat. No.: HY-P10828
CAS No.: 1260620-30-1
Target:  

Virus Protease

연구분야:  

Infection Inflammation/Immunology

MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .
Z-Pro-Pro-aldehyde-dimethyl acetal
Z-Pro-Pro-aldehyde-dimethyl acetal
0 Images
Cat. No.: HY-P4308
CAS No.: 170116-63-9
Target:  

Prolyl Endopeptidase (PREP)

연구분야:  

Neurological Disease

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease .
KK-103
KK-103
0 Images
Cat. No.: HY-P6053
CAS No.: 2775287-98-2
Target:  

Opioid Receptor

연구분야:  

Neurological Disease

KK-103 is a precursor of leucine-enkephalin (Leu-ENK) overcomes high proteolytic instability of Leu-ENK via markedly increased plasma stability in mice that has antinociceptive effect .
A3-APO
A3-APO
0 Images
Cat. No.: HY-P11004
Target:  

Bacterial Antibiotic

연구분야:  

Infection

A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .
Azaline B
Azaline B
0 Images
Cat. No.: HY-P10472
CAS No.: 134457-28-6
Target:  

GnRH Receptor

연구분야:  

Endocrinology

Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
Assay Types