2580150-96-3
Chemical Structure
Noraramtide
Synonym(s): BHV-1100
- CAS No.: 2580150-96-3
- Formula:C210H300N48O65S3
- Molecular Weight:4633.11
SMILES: CCCCC[C@H]1C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CC=C(C5=CC=CC=C5)C=C4)C(N[C@@H](CCCCC)C(N[C@@H](CC(O)=O)C(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCN6C7=C(N=N6)CC[C@H]8[C@@H](CC7)[C@H]8COC(N9CCC(C(NCC(N[C@H](C(O)=O)CCC(N[C@@H](C(O)=O)CCC(N[C@@H](C(N[C@@H](C(O)=O)CCC(N[C@@H](C(O)=O)CCC(NCC(NCC(N[C@H](C(N[C@H]%10CSSC[C@@H](C(N[C@H](C(O)=O)[C@H](O)C)=O)NC([C@H](CC%11=CNC%12=CC=CC=C%12%11)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC(CNC([C@H](CC(C)C)NC([C@H](CC%13=CNC=N%13)NC([C@H](CC%14=CNC%15=CC=CC=C%15%14)NC([C@H](C)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)=O)=O)=O)CC9)=O)=O)CSCC(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma[1].
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Noraramtide | Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma. | |||||||||||||||||||||
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Keywords
