99828-55-4
Chemical Structure
MMP-2/MMP-9 Substrate
Synonym(s): Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
- CAS No.: 99828-55-4
- Formula:C31H53N5O8S
- Molecular Weight:655.85
InChIKey: OJIFMDRLHMGYGK-QORCZRPOSA-N
SMILES: CCOC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)SC(CNC([C@H](CC(C)C)NC([C@H]1N(CCC1)C(C)=O)=O)=O)=O)=O)=O)=O
Biological Activity: MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties[1][2].
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MMP-2/MMP-9 Substrate | 98.48% | MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties. | ||||||||||||||||||||
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- [1]. Weingarten H, et al. Spectrophotometric assay for vertebrate collagenase. Anal Biochem. 1985;147(2):437-440. [Content Brief]
- [2]. Lupia E, et al. Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9. Lab Invest. 2012;92(2):236-245. [Content Brief]
Keywords
