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Cat. No.: HY-184560

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VL285-PEG3-I

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405).

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CAS No.: 2254609-31-7
화학식: C₃₅H₄₃IN₄O₇S
분자량:790.71

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

VL285-PEG3-I Chemical Structure

CAS No.: 2254609-31-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
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References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

E3 ligase ligand-linker conjugates are components of proteolysis-targeting chimeras (PROTACs). They consist of a ligand for an E3 ubiquitin ligase and a linker, and when connected to a ligand for a target protein (e.g., JQ1 binds to BRD4, Molibresib binds to BET proteins), they can be used to construct PROTACs that induce ubiquitination and degradation of the target protein.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2254609-31-7
분자량 790.71
화학식 C₃₅H₄₃IN₄O₇S
SMILES

ICCOCCOCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4C(C5=CC=CC=C5C4)=O)C(C)C)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Smith BE, et al.. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nature communications. 2019 Jan 10;10(1):131. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
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VL285-PEG3-I

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VL285-PEG3-I Related Classifications

HY-184560 Related Classifications