1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Potassium Channel
    Calcium Channel
  3. Lidoflazine

Lidoflazine 

Cat. No.: HY-112075 Purity: >98.0%
Handling Instructions

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia.

For research use only. We do not sell to patients.

Lidoflazine Chemical Structure

Lidoflazine Chemical Structure

CAS No. : 3416-26-0

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10 mM * 1 mL in DMSO USD 946 In-stock
Estimated Time of Arrival: December 31
10 mg USD 860 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia[1].

IC50 & Target

Ca2+

 

In Vitro

Lidoflazine inhibits potently HERG current (IHERG) recorded from HEK 293 cells stably expressing wild-type HERG (IC50 of ~16 nM).

Molecular Weight

491.62

Formula

C₃₀H₃₅F₂N₃O

CAS No.

3416-26-0

SMILES

O=C(NC1=C(C)C=CC=C1C)CN2CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

LidoflazinePotassium ChannelCalcium ChannelKcsACa2+ channelsCa channelsInhibitorinhibitorinhibit

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Lidoflazine
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