2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MD 220661

MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism.

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MD 220661

MD 220661 Chemical Structure

CAS No. : 73423-35-5

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MD 220661 Related Antibodies

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MAO-A MAO-B

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Description

MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism[1].

IC50 & Target[1]

MAO-A

 

MAO-B

 

In Vitro

MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat aorta homogenates with an initial IC50 of 3.0 μM, but its inhibitory potency decreases significantly with preincubation time, indicating it acts as both an inhibitor and substrate of the enzyme[1].
MD 220661 inhibits semicarbazide-sensitive amine oxidase in rat heart homogenates with an initial IC50 of 1.9 μM, and its inhibitory potency decreases with preincubation time, consistent with it acting as both an inhibitor and substrate of the enzyme[1].
MD 220661 inhibits monoamine oxidase A in rat aorta homogenates, and its inhibitory potency decreases significantly with preincubation time in the absence of semicarbazide, but only slightly in the presence of semicarbazide[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MD 220661 Related Antibodies
In Vivo

MD 220661 (10-50 mg/kg; i.v.; single dose) does not produce significant inhibition of rat heart SSAO activity when measured 15 minutes post-administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

332.78

Formula

C17H17ClN2O3
CAS No.
SMILES

O=C1OC(CN1C2=CC=C(C=C2)OCC3=CC=CC(Cl)=C3)CN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MD 220661 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD 22066173423-35-5MD220661MD-220661Monoamine OxidaseMAOMAO-Brat tissuesrat aorta homogenatesrat brainmonoamine oxidaserat heart homogenatesMAO-Asemicarbazide-sensitive amine oxidaserat heartInhibitorinhibitorinhibit

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