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(-)-Cleistenolide (Synonyms: Cleistenolide)

Cat. No.: HY-N10391
Handling Instructions

(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity.

For research use only. We do not sell to patients.

(-)-Cleistenolide Chemical Structure

(-)-Cleistenolide Chemical Structure

CAS No. : 1003600-48-3

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Description

(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity[1].

In Vitro

(-)-Cleistenolide (compound 1) exhibits potent cytotoxicity against cancer cell lines and low cytotoxicity in normal cells MRC-5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay

Cell Line: K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549 and MRC-5[1]
Concentration: 0-100 μM
Incubation Time:
Result: Exhibited potent cytotoxicity against cancer cell lines with IC50s of 7.65 μM, 1.21 μM, 14.22 μM, 36.94 μM, 26.07 μM, 2.25 μM, 7.32 μM and 16.34 μM in K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa and A549, respectively; and had low cytotoxicity in normal cells MRC-5 with an IC50 over 100 μM.
Molecular Weight

362.33

Formula

C18H18O8

CAS No.
SMILES

CC(O[[email protected]@H]1C=CC(O[[email protected]@H]1[[email protected]](OC(C)=O)COC(C2=CC=CC=C2)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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(-)-Cleistenolide
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