2. Metabolic Enzyme/Protease
  3. MAGL
  4. MJN110

MJN110 

Cat. No.: HY-117474 Purity: 99.57%
COA Handling Instructions

MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity.

For research use only. We do not sell to patients.

MJN110 Chemical Structure

MJN110 Chemical Structure

CAS No. : 1438416-21-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 99 In-stock
25 mg USD 220 In-stock
50 mg USD 352 In-stock
100 mg USD 627 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

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Description

MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively[1]. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity[2].

IC50 & Target

IC50: 9.1 nM (hMAGL) and 2.1 nM (2-AG)[1]
In Vitro

MJN110 (0.01-1000 nM; 4 hours) has the primary serine hydrolase target, hMAGL, with an IC50 of ~1 nM and 10- and 100-fold selectivity windows over ABHD6 and LYPLA1/2, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Human-derived PC3 cells
Concentration: 0.01, 0.1, 1, 10, 100, 1000 nM
Incubation Time: 4 hours
Result: HMAGL acted as the primary serine hydrolase target with an IC50 of ~1 nM.
In Vivo

MJN110 (i.p.; 0.0818 mg/kg; twice daily for 5.5 days) reverses chronic constriction injury (CCI)-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner. The respective ED50 value (95% confidence limits) is 0.430 (0.233-0.793) mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice ranged from 18 to 35 g[1]
Dosage: 0.0818 mg/kg
Administration: I.p.; twice daily for 5.5 days
Result: Reversed CCI-induced mechanical allodynia and thermal hyperalgesia in a dose-dependent manner.
Molecular Weight

462.33

Appearance

Solid

Formula

C22H21Cl2N3O4
CAS No.
SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)ON4C(CCC4=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (540.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1630 mL 10.8148 mL 21.6296 mL
5 mM 0.4326 mL 2.1630 mL 4.3259 mL
10 mM 0.2163 mL 1.0815 mL 2.1630 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.50 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.57%

COA (250 KB) HNMR (190 KB) LCMS (120 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

MJN1101438416-21-7MJN 110MJN-110MAGLMonoacylglycerol lipaseInhibitorinhibitorinhibit

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