1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. NCT-501 hydrochloride

NCT-501 hydrochloride 

Cat. No.: HY-18768A
Handling Instructions

NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).

For research use only. We do not sell to patients.

NCT-501 hydrochloride Chemical Structure

NCT-501 hydrochloride Chemical Structure

CAS No. : 2080306-22-3

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Description

NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM)[1][2].

IC50 & Target

IC50: 40 nM (hALDH1A1)[2]

In Vitro

NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant[1].

In Vivo

NCT-501 (100 µg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts[1].

Molecular Weight

452.98

Formula

C₂₁H₃₃ClN₆O₃

CAS No.

2080306-22-3

SMILES

O=C(N1C)N(C)C2=C(N(CCC(C)C)C(CN3CCN(C(C4CC4)=O)CC3)=N2)C1=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NCT-501NCT501NCT 501Aldehyde Dehydrogenase (ALDH)Inhibitorinhibitorinhibit

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NCT-501 hydrochloride
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