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NP-G2-044 

Cat. No.: HY-125506 Purity: 99.76%
COA Handling Instructions

NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.

For research use only. We do not sell to patients.

NP-G2-044 Chemical Structure

NP-G2-044 Chemical Structure

CAS No. : 1807454-59-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 145 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 198 In-stock
Estimated Time of Arrival: December 31
25 mg USD 418 In-stock
Estimated Time of Arrival: December 31
50 mg USD 638 In-stock
Estimated Time of Arrival: December 31
100 mg USD 957 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NP-G2-044

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response[1][2].

In Vitro

NP-G2-044 inhibits the migration of MDA-MB-231 tumor cells with an IC50 ~10 μM. NP-G2-044 decreases filopodial formation resulting in decreased lamellipodial formation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

NP-G2-044 (100 mg/kg; i.p.; daily for 18 days) inhibits breast tumor metastasis in mouse models[1].
Upon oral administration, NP-G2-044 targets and binds to fascin, thereby preventing the interaction of fascin with actin filaments, thereby preventing actin bundling and filopodia formation. By preventing actin cytoskeletal reorganization, the dynamic changes in cell shape that are necessary for tumor cell migration and invasion to occur are impaired, and tumor cell migration and metastasis are inhibited[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week old female BALB/c mice (mouse model bearing 4T1 tumor cells)[1]
Dosage: 100 mg/kg
Administration: I.p.; daily for 18 days
Result: Inhibition of 4T1 mouse mammary tumor cell metastasis to the lung.
Clinical Trial
Molecular Weight

399.37

Appearance

Solid

Formula

C21H16F3N3O2
CAS No.
SMILES

O=C(C1=C(C)OC=C1)NC2=NN(CC3=CC=C(C(F)(F)F)C=C3)C4=C2C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (250.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5039 mL 12.5197 mL 25.0394 mL
5 mM 0.5008 mL 2.5039 mL 5.0079 mL
10 mM 0.2504 mL 1.2520 mL 2.5039 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.26 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

NP-G2-0441807454-59-6OthersactinfilamentsfascinfilopodialformationcellmigrationmetastasisInhibitorinhibitorinhibit

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