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NP-G2-044 

Cat. No.: HY-125506 Purity: 99.45%
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NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.

For research use only. We do not sell to patients.

NP-G2-044 Chemical Structure

NP-G2-044 Chemical Structure

CAS No. : 1807454-59-6

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Based on 1 publication(s) in Google Scholar

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Description

NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response[1][2].

In Vitro

NP-G2-044 inhibits the migration of MDA-MB-231 tumor cells with an IC50 ~10 μM. NP-G2-044 decreases filopodial formation resulting in decreased lamellipodial formation[1].

In Vivo

NP-G2-044 (100 mg/kg; i.p.; daily for 18 days) inhibits breast tumor metastasis in mouse models[1].
Upon oral administration, NP-G2-044 targets and binds to fascin, thereby preventing the interaction of fascin with actin filaments, thereby preventing actin bundling and filopodia formation. By preventing actin cytoskeletal reorganization, the dynamic changes in cell shape that are necessary for tumor cell migration and invasion to occur are impaired, and tumor cell migration and metastasis are inhibited[3].

Animal Model: 6-8 week old female BALB/c mice (mouse model bearing 4T1 tumor cells)[1]
Dosage: 100 mg/kg
Administration: I.p.; daily for 18 days
Result: Inhibition of 4T1 mouse mammary tumor cell metastasis to the lung.
Molecular Weight

399.37

Formula

C₂₁H₁₆F₃N₃O₂

CAS No.

1807454-59-6

SMILES

O=C(C1=C(C)OC=C1)NC2=NN(CC3=CC=C(C(F)(F)F)C=C3)C4=C2C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

NP-G2-044OthersactinfilamentsfascinfilopodialformationcellmigrationmetastasisInhibitorinhibitorinhibit

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NP-G2-044
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HY-125506
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