Araliadiol
Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cells growth with an IC50 value of 6.41 μg/mL.
For research use only. We do not sell to patients.
- CAS No.: 1354638-93-9
- Formula: C15H20O2
- Molecular Weight:232.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 6.41 µg/mL (MCF-7 cells growth)[1]
Araliadiol (20-80 μM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition[1].
Araliadiol (20-80 μM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D3 and cdk4 and an increase in the expression of p21 (WAF-1/Cip1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:20 µM, 40 µM, and 80 µM
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Incubation Time:0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours
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Result:The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %).
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Cell Line:MCF-7 cells
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Concentration:20 µM, 40 µM, and 80 µM
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Incubation Time:48 hours
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Result:Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1).
Chemical Information
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CAS No. 1354638-93-9
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Molecular Weight 232.32
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Formula C15H20O2
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SMILES
C=C[C@H](O)C#CC#C[C@H](O)/C=C\CCCCC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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