BMS-187308
BMS-187308 is an orally active endothelin-A (ETA) antagonist, with Kis of 4.7 nM for ETA and 1.7 μM for ETB. BMS-187308 inhibits the pressor response to ET-1 (ED25: 1.2 µmol/kg; iv). BMS-187308 is a suitable tool for investigating the role of endothelin.
For research use only. We do not sell to patients.
- CAS No.: 153624-15-8
- Formula: C21H25N3O3S
- Molecular Weight:399.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ETA 4.7 nM (Ki) |
ETB 1.7 μM (Ki) |
Chemical Information
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CAS No. 153624-15-8
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Molecular Weight 399.51
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Formula C21H25N3O3S
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SMILES
O=S(C1=CC=CC=C1C2=CC=C(CC(C)C)C=C2N)(NC3=C(C)C(C)=NO3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Murugesan N, et al. Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308). J Med Chem. 1998 Dec 17;41(26):5198-218. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-187308 Related Classifications
HY-117814 Related Classifications
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