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Cat. No.: HY-160633

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PfFAS-II inhibitor 1

PfFAS-II inhibitor 1 (Compound 3) is a Plasmodium falciparum type II fatty acid biosynthesis pathway (PfFAS-II) inhibitor, with an IC₅₀ of 0.63 μM for PfFabI enzyme. PfFAS-II inhibitor 1 has antimalarial activity.

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CAS No.: 1459704-68-7
화학식: C₁₅H₉ClO₄
분자량:288.68

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PfFAS-II inhibitor 1 Chemical Structure

CAS No.: 1459704-68-7

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Plasmodium falciparum Type II Fatty Acid Biosynthesis Pathway (PfFAS-II)^[1]

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	96.2 μM Compound: 3	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis	[PMID: 24063369]

Chemical Information

CAS No. 1459704-68-7
분자량 288.68
화학식 C₁₅H₉ClO₄
SMILES

O=C1OC2=C(C=C1)C=C(OC3=CC=C(C=C3O)Cl)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Belluti F, et al. Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem. 2013 Oct 10;56(19):7516-26. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- IC50 & Target
Chemical Information
순도&문서
References

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