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Phoyunnanin E 

Cat. No.: HY-N9489
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Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer.

For research use only. We do not sell to patients.

Phoyunnanin E Chemical Structure

Phoyunnanin E Chemical Structure

CAS No. : 886747-60-0

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Description

Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer[1].

In Vitro

Phoyunnanin E (0~10 μM; 48 hours; H460 cells) decreases cell migration through integrin downregulation[1].
Phoyunnanin E (0~100 μM; 24 and 48 hours; H460 cells) shows that the proliferation rate of treated cells have significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 hours[1].
Phoyunnanin E (0~100 μM; 24 hours; H460 cells) induces cytotoxic effects at the concentrations from 50 to 100 μM and induces a significant increase in apoptotic and necrotic cells at 20~100 μM[1].
Phoyunnanin E (0~10 μM; 48 hours; H460, H292 and A549 cells) significantly decreases the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner[1].
Phoyunnanin E attenuates anchorage-independent growth and migration of lung cancer H460 cells. Phoyunnanin E significantly inhibits cell migration across the wound space at the concentrations of 5 and 10 μM, at 24 h and 48 h, compared to the non-treated control. Phoyunnanin E (0~10 μM; 48 hours) exhibits a significant decrease in filopodia numbers at the protrusion edges of the cells in a dose-dependent manner. Phoyunnanin E decreases cancer cell migration in other human lung cancer cells. Phoyunnanin E decreases cancer cell invasion. Phoyunnanin E suppresses epithelial-mesenchymal transition (EMT). Phoyunnanin E down-regulates integrins αv and β3 and the regulatory proteins in cell migration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1~10 μM
Incubation Time: 48 hours
Result: Decreased cell migration through integrin downregulation.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 and 48 hours
Result: The proliferation rate of treated cells had significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 h.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced a significant increase in apoptotic and necrotic cells at 20~100 μM.

Cell Cytotoxicity Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced cytotoxic effects at the concentrations from 50 to 100 μM.

Immunofluorescence[1]

Cell Line: H460, H292 and A549 cells
Concentration: 0~10 μM
Incubation Time: 48 hours
Result: Significantly decreased the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner.
Molecular Weight

482.52

Formula

C₃₀H₂₆O₆

CAS No.
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Phoyunnanin E
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