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  4. Orchidaceae Cancer Polyphenols
  5. Dendrobium nobile Lindl.
  6. Phoyunnanin E

Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer.

For research use only. We do not sell to patients.

Phoyunnanin E Chemical Structure

Phoyunnanin E Chemical Structure

CAS No. : 886747-60-0

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Phoyunnanin E Related Antibodies

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Description

Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer[1].

In Vitro

Phoyunnanin E (0~10 μM; 48 hours; H460 cells) decreases cell migration through integrin downregulation[1].
Phoyunnanin E (0~100 μM; 24 and 48 hours; H460 cells) shows that the proliferation rate of treated cells have significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 hours[1].
Phoyunnanin E (0~100 μM; 24 hours; H460 cells) induces cytotoxic effects at the concentrations from 50 to 100 μM and induces a significant increase in apoptotic and necrotic cells at 20~100 μM[1].
Phoyunnanin E (0~10 μM; 48 hours; H460, H292 and A549 cells) significantly decreases the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner[1].
Phoyunnanin E attenuates anchorage-independent growth and migration of lung cancer H460 cells. Phoyunnanin E significantly inhibits cell migration across the wound space at the concentrations of 5 and 10 μM, at 24 h and 48 h, compared to the non-treated control. Phoyunnanin E (0~10 μM; 48 hours) exhibits a significant decrease in filopodia numbers at the protrusion edges of the cells in a dose-dependent manner. Phoyunnanin E decreases cancer cell migration in other human lung cancer cells. Phoyunnanin E decreases cancer cell invasion. Phoyunnanin E suppresses epithelial-mesenchymal transition (EMT). Phoyunnanin E down-regulates integrins αv and β3 and the regulatory proteins in cell migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phoyunnanin E Related Antibodies

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1~10 μM
Incubation Time: 48 hours
Result: Decreased cell migration through integrin downregulation.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 and 48 hours
Result: The proliferation rate of treated cells had significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 h.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced a significant increase in apoptotic and necrotic cells at 20~100 μM.

Cell Cytotoxicity Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced cytotoxic effects at the concentrations from 50 to 100 μM.

Immunofluorescence[1]

Cell Line: H460, H292 and A549 cells
Concentration: 0~10 μM
Incubation Time: 48 hours
Result: Significantly decreased the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner.
Molecular Weight

482.52

Formula

C30H26O6
CAS No.
SMILES

OC1=CC=C2C(CCC3=C(C(OC)=CC(O)=C23)OC4=CC=C5C(CCC6=CC(OC)=CC(O)=C56)=C4)=C1
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phoyunnanin E886747-60-0OthersDendrobiumvenustumanti-migrationcancerH460Inhibitorinhibitorinhibit

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