2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. PMX 53 monoacetate

PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2.

For research use only. We do not sell to patients.

CAS No. : 852629-88-0

Size Price Stock Quantity
1 mg Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
5 mg Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
10 mg Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
50 mg   Get quote  
100 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of PMX 53 monoacetate:

PMX 53 monoacetate Related Antibodies

Top Publications Citing Use of Products

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523.  [Abstract]

    Chemotaxis of THP1 cells toward medium without FBS (control), medium without FBS + 0.1 μg/mL of C5a (C5a), and THP1 cells pre-treated 30 min with 0.9 μg/mL PMX53 toward medium without FBS + 0.1 μg/mL C5a (PMX53 + C5a) was evaluated. After 2 h of migration, RFU (Ex/Em = 485/520 nm) was measured.

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523.  [Abstract]

    Western blotting of phosphoS6, phosphoHSP27, phosphoERK, and the loading control β-actin of THP1 cells untreated or treated with PMX53 (0.9 μg/mL) and/or C5a for 30 min. The experiment was performed three times with similar results.

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523.  [Abstract]

    Chemotaxis of primary monocytes isolated from WT and C5aR1-/- mice toward medium without FBS, medium without FBS + 0.1 μg/mL of C5a (C5a). Migration of WT monocytes pre-treated for 30 min with 0.9 μg/mL PMX53 toward medium without FBS + 0.1 μg/mL C5a was also evaluated n = 4–6.

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523.  [Abstract]

    Schematic representation of the pharmacological inhibition of C5aR1 in the DoxoR-induced senescence model. At day 0, 15-week-old mice received either vehicle or DoxoR (10 mg/kg, i.p.). From day 1 to day 30, mice received PMX53 (1 mg/kg, daily subcutaneous) or vehicle 2.

    PMX 53 monoacetate purchased from MedChemExpress. Usage Cited in: Mol Ther. 2023 Aug 2;31(8):2507-2523.  [Abstract]

    Schematic representation of the pharmacological inhibition of C5aR1 in the DoxoR-induced senescence model. At day 0, 15-week-old mice received either vehicle or DoxoR (10 mg/kg, i.p.). From day 1 to day 30, mice received PMX53 (1 mg/kg, daily subcutaneous) or vehicle 2. Quantitative parameters and 3D representation of the cortical bone of tibiae measured by μ-CT.

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2[1].

    Molecular Weight

    956.14

    Formula

    C49H69N11O9
    CAS No.
    SMILES

    CC(O)=O.O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@H](CCCNC([C@@H](NC2=O)CCCNC(N)=N)=O)NC([C@@H](NC(C)=O)CC3=CC=CC=C3)=O)=O)=O)CC4CCCCC4)N[C@H]2CC5=CNC6=CC=CC=C56
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    PMX 53 monoacetate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PMX 53 monoacetate852629-88-03D53 monoacetateEndogenous MetaboliteInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    PMX 53 monoacetate
    Cat. No.:
    HY-106178D
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.