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Results for "

4-1bb-cd137

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (1) Claudin (1) TNF Receptor (5) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (5) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99056

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to *4-1BB/CD137*. Utomilumab can be used in the research of tumors such as follicular and other CD20 ⁺ non-Hodgkin lymphomas .

HY-P99119

*Anti-Mouse 4-1BB/CD137* Antibody (3H3)**	TNF Receptor Bcl-2 Family	Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse *4-1BB/CD137* IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer .

HY-P990742

Givastomig TJ-cd4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P990809

*Anti-Mouse 4-1BB/CD137* Antibody (LOB12.3)**	TNF Receptor	Infection Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse *4-1BB/CD137. Anti-Mouse 4-1BB/CD137* Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection .

HY-P99119A

*Anti-Mouse 4-1BB/CD137* (LALA-PG) Antibody (LOB12.3)**	TNF Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a mouse-derived IgG2a κ type antibody agonist, targeting to mouse *4-1BB/CD137. Anti-Mouse 4-1BB/CD137* (LALA-PG) Antibody (LOB12.3) is a chimeric antibody of the original LOB12.3 antibody (HY-P990809). Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) contains the LALA-PG mutation region. Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease.

HY-P991095

ALG.APV-527 APV-527; ATOR-1016	Transmembrane Glycoprotein	Cancer
ALG.APV-527 (APV-527) is a bispecific *4-1BB (CD137)* and 5T4 antibody. ALG.APV-527 is designed to activate 4-1BB on T and natural killer (NK) cells only when simultaneously bound to 5T4-expressing tumor cells. ALG.APV-527 has a potent antitumor activity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99056

Utomilumab PF 05082566	TNF Receptor	Inflammation/Immunology Cancer
Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to *4-1BB/CD137*. Utomilumab can be used in the research of tumors such as follicular and other CD20 ⁺ non-Hodgkin lymphomas .

HY-P99119

*Anti-Mouse 4-1BB/CD137* Antibody (3H3)**	TNF Receptor Bcl-2 Family	Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse *4-1BB/CD137* IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer .

HY-P990742

Givastomig TJ-cd4B; ABL111; TJ033721	TNF Receptor Claudin	Inflammation/Immunology Cancer
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma .

HY-P990809

*Anti-Mouse 4-1BB/CD137* Antibody (LOB12.3)**	TNF Receptor	Infection Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic mouse-derived IgG2a κ antibody, targeting to mouse *4-1BB/CD137. Anti-Mouse 4-1BB/CD137* Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection .

HY-P99119A

*Anti-Mouse 4-1BB/CD137* (LALA-PG) Antibody (LOB12.3)**	TNF Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a mouse-derived IgG2a κ type antibody agonist, targeting to mouse *4-1BB/CD137. Anti-Mouse 4-1BB/CD137* (LALA-PG) Antibody (LOB12.3) is a chimeric antibody of the original LOB12.3 antibody (HY-P990809). Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) contains the LALA-PG mutation region. Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease.

HY-P991095

ALG.APV-527 APV-527; ATOR-1016	Transmembrane Glycoprotein	Cancer
ALG.APV-527 (APV-527) is a bispecific *4-1BB (CD137)* and 5T4 antibody. ALG.APV-527 is designed to activate 4-1BB on T and natural killer (NK) cells only when simultaneously bound to 5T4-expressing tumor cells. ALG.APV-527 has a potent antitumor activity .

Species:	Mouse (1) Rat (1) Rabbit (1)
Tag:	His (3) Avi (1)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78599

	4-1BB/TNFRSF9 Protein, Rabbit (HEK293, His) TNFRSF9; 4-1bb; cd137; cdw137; ILA	Rabbit	HEK293
	4-1BB/TNFRSF9 Protein lacks conserved residue(s) crucial for feature annotation propagation. 4-1BB/TNFRSF9 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived 4-1BB/TNFRSF9 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78614

	4-1BB/TNFRSF9 Protein, Rat (HEK293, His) TNFRSF9; 4-1bb; cd137; cdw137; ILA	Rat	HEK293
	4-1BB/TNFRSF9 protein is deficient in the conserved residue(s) necessary for propagating feature annotation. 4-1BB/TNFRSF9 Protein, Rat (HEK293, His) is the recombinant rat-derived 4-1BB/TNFRSF9 protein, expressed by HEK293 , with C-His labeled tag. The total length of 4-1BB/TNFRSF9 Protein, Rat (HEK293, His) is 164 a.a., with molecular weight of 28-38 kDa.

HY-P78794

	4-1BB/TNFRSF9 Protein, Mouse (Biotinylated, 188a.a, HEK293, His-Avi) TNFRSF9; 4-1bb; cd137; cdw137; ILA	Mouse	HEK293
	4-1BB/TNFRSF9 Protein lacks conserved residue(s) crucial for feature annotation propagation. 4-1BB/TNFRSF9 Protein, Mouse (Biotinylated, 188a.a, HEK293, His-Avi) is the recombinant mouse-derived 4-1BB/TNFRSF9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of 4-1BB/TNFRSF9 Protein, Mouse (Biotinylated, 188a.a, HEK293, His-Avi) is 188 a.a., with molecular weight of 30-45 kDa.

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HY-P81761

	CD137/4-1BB Antibody (YA1506) TNFRSF9; 4-1bb; cd137; cdw137; ILA	FC, ELISA	Human
	CD137/4-1BB Antibody (YA1506) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD137/4-1BB.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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