2. GPCR/G Protein Neuronal Signaling Cell Cycle/DNA Damage
  3. Cannabinoid Receptor PERK
  4. RD-pepcan-11

RD-pepcan-11 is a CB1 receptor agonist. RD-pepcan-11 increases the relative phosphorylation level of ERK1/2. RD-pepcan-11 mediates analgesic effects through interaction with CB1 receptors in a carrageenan-induced mouse inflammatory pain model. RD-pepcan-11 can be used in studies related to inflammatory pain.

For research use only. We do not sell to patients.

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RD-pepcan-11

RD-pepcan-11 Chemical Structure

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RD-pepcan-11 Related Antibodies

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Description

RD-pepcan-11 is a CB1 receptor agonist. RD-pepcan-11 increases the relative phosphorylation level of ERK1/2. RD-pepcan-11 mediates analgesic effects through interaction with CB1 receptors in a carrageenan-induced mouse inflammatory pain model. RD-pepcan-11 can be used in studies related to inflammatory pain[1].

IC50 & Target[1]

CB1

 

In Vitro

RD-pepcan-11 (300 μM; 10 min) acts as a CB1 receptor agonist in CB1-overexpressing CHO-K1 cells, with increased agonist activity observed at a concentration of 300 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RD-pepcan-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: CB1 receptor-overexpressing CHO-K1 cells
Concentration: 300 μM
Incubation Time: 10 min
Result: Exhibited higher agonist activity toward the CB1 receptor, as indicated by increased ERK1/2 phosphorylation relative to control conditions.
In Vivo

RD-pepcan-11 (3.25-30 nM/mouse; administered intratracheally) exerts a dose-dependent, CB1 receptor-mediated analgesic effect in a carrageenan-induced mouse model of inflammatory pain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (male, 6-8 weeks old, 25 g)[1]
Dosage: 3.25, 7.5, 15, 30 nM/mouse
Administration: i.t.
Result: Produced significantly higher AUC values than normal saline control at 7.5, 15, and 30 nM per mouse.
Demonstrated peak antinociceptive effect and AUC value slightly exceeding positive control WIN55212-2 (7.5 nM per mouse) at 30 nM per mouse.
Had antinociceptive effects almost completely blocked by CB1 receptor antagonist AM251 pretreatment.
Showed no significant attenuation of antinociceptive effects by CB2 receptor antagonist AM630 pretreatment.
Molecular Weight

1191.34

Formula

C52H86N16O16
Sequence

Ser-Ala-Leu-Ser-Asp-Leu-His-Ala-His-Lys-Leu
Sequence Shortening

SALSDLHAHKL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RD-pepcan-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RD-pepcan-11Cannabinoid ReceptorPERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseendogenous cannabinoid systemmolecular dynamics simulationcarrageenan-induced inflammatory painantinociceptive effectsCB1 receptorCB2 receptorCHO-K1 cellsmouseInhibitorinhibitorinhibit

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