1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. SB 218795

SB 218795 

Cat. No.: HY-107692
Handling Instructions

SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.

For research use only. We do not sell to patients.

SB 218795 Chemical Structure

SB 218795 Chemical Structure

CAS No. : 174635-53-1

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Description

SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit[1][2].

IC50 & Target[1]

hNK3

13 nM (Ki)

hNK2

1220 nM (Ki)

In Vitro

SB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner[2].
SB 218795 (0.3-3 μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.44

Formula

C₂₅H₂₀N₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SB 218795
Cat. No.:
HY-107692
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