SB 218795 (Standard)
SB 218795 (Standard) is the analytical standard of SB 218795 (HY-107692). This product is intended for research and analytical applications. SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 174635-53-1
- 分子式: C25H20N2O3
- 分子量:396.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-P0187
SenktideNK3 Receptor Agonist -
HY-107692
SB 218795NK3 Receptor Antagonist -
HY-15722
SB-222200NK-3 Receptor Antagonist -
HY-14552
TalnetantNK3 Receptor Antagonist -
HY-P0197
Neurokinin APeptide Neurotransmitter -
HY-19632
FezolinetantNK3R Antagonist -
HY-12142
VofopitantNK1 Receptor Antagonist -
HY-109171
ElinzanetantNK-1/NK-3 Receptor Antagonist -
![[Sar9,Met(O2)11]-Substance P](https://file.medchemexpress.com/product_pic/hy-p1012.gif)
HY-P1012
[Sar9,Met(O2)11]-Substance PTachykinin NK1 Receptor Agonist -
HY-101249
L-732138NK-1 Receptor Antagonist -
HY-14432
PavinetantNeurokinin Receptor Antagonist -
HY-16732
TradipitantNK-1 Receptor Antagonist
生物活性
製品説明
化学情報
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CAS 番号 174635-53-1
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分子量 396.44
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分子式 C25H20N2O3
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SMILES
COC([C@@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=CC=C3)=NC4=CC=CC=C24)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Giardina GA, et, al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. J Med Chem. 1997 Jun 6;40(12):1794-807. [Content Brief]
[2]. Medhurst AD, et, al. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br J Pharmacol. 1997 Oct;122(3):469-76. [Content Brief]
[3]. Valero MS, et, al. Contractile effect of tachykinins on rabbit small intestine. Acta Pharmacol Sin. 2011 Apr;32(4):487-94. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB 218795 (Standard) 関連分類
HY-107692R 関連分類
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