Dowicil 200
Based on 1 Customer Validation
Dowicil 200 (Quaternium-15) is a skin toxin and allergen that inhibits the growth of Pinctada fucata cells. Dowicil 200 has antimicrobial activity and is more potent against fungi and molds than against fungi.
For research use only. We do not sell to patients.
- Purity: 98.89%
- CAS No.: 51229-78-8
- Formula: C9H16Cl2N4
- Molecular Weight:251.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
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Antibacterial Compound Library
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Inactive Ingredient Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Cosmetic Ingredient Compound Library
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Biological Activity
Chemical Information
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CAS No. 51229-78-8
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Appearance Solid
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Molecular Weight 251.16
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Formula C9H16Cl2N4
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Color White to off-white
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SMILES
Cl/C=C\C[N+]12C[N@]3C[N@@](C2)C[N@@](C1)C3.[Cl-]
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Synonyms
Quaternium-15
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 15.62 mg/mL (62.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.56 mg/mL (6.21 mM); Clear solution
This protocol yields a clear solution of ≥ 1.56 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.56 mg/mL (6.21 mM); Clear solution
This protocol yields a clear solution of ≥ 1.56 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (913 KB)
- English - EN (913 KB)
- Français - FR (913 KB)
- Deutsch - DE (913 KB)
- Norwegian - NO (913 KB)
- Español - ES (913 KB)
- Swedish - SV (913 KB)
- Italian - IT (913 KB)
- Korean - KR (913 KB)
- Portuguese - PT (913 KB)
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Handling Instructions (2659 KB)
References
[1]. Biebl KA, et al. Allergic contact dermatitis to cosmetics. Dermatol Clin. 2006 Apr;24(2):215-32, vii. [Content Brief]
[2]. Multisanti CR, et al. Short-term in vitro exposure of Pinctada imbricata's haemocytes to quaternium-15: Exploring physiological and cellular responses. Environ Toxicol Pharmacol. 2023;101:104198. [Content Brief]
[3]. Silverberg JI, et al. Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001-2016. Arch Dermatol Res. 2022;314(9):857-867. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9815 mL | 19.9076 mL | 39.8153 mL | 99.5381 mL |
| 5 mM | 0.7963 mL | 3.9815 mL | 7.9631 mL | 19.9076 mL | |
| 10 mM | 0.3982 mL | 1.9908 mL | 3.9815 mL | 9.9538 mL | |
| 15 mM | 0.2654 mL | 1.3272 mL | 2.6544 mL | 6.6359 mL | |
| 20 mM | 0.1991 mL | 0.9954 mL | 1.9908 mL | 4.9769 mL | |
| 25 mM | 0.1593 mL | 0.7963 mL | 1.5926 mL | 3.9815 mL | |
| 30 mM | 0.1327 mL | 0.6636 mL | 1.3272 mL | 3.3179 mL | |
| 40 mM | 0.0995 mL | 0.4977 mL | 0.9954 mL | 2.4885 mL | |
| 50 mM | 0.0796 mL | 0.3982 mL | 0.7963 mL | 1.9908 mL | |
| 60 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.6590 mL |
Dowicil 200 Related Classifications
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