GRM2 - glutamate metabotropic receptor 2 Gene

Also Known as GLUR2; mGlu2; GPRC1B; MGLUR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2912

About GRM2

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,707,068-51,718,613 (from NCBI)

This gene has 8 transcripts (splice variants), 277 orthologues and 7 paralogues. Biased expression in testis (RPKM 2.8), brain (RPKM 2.2) and 4 other tissues.

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

GRM2 Products (15)

mRNA	Protein	Name
XM_011533637.2	XP_011531939.1	metabotropic glutamate receptor 2 isoform X4
XM_047448047.1	XP_047304003.1	metabotropic glutamate receptor 2 isoform X2
XM_047448048.1	XP_047304004.1	metabotropic glutamate receptor 2 isoform X4
NR_146059.2
XM_047448049.1	XP_047304005.1	metabotropic glutamate receptor 2 isoform X4
XM_011533636.2	XP_011531938.1	metabotropic glutamate receptor 2 isoform X3
XM_017006271.2	XP_016861760.1	metabotropic glutamate receptor 2 isoform X1
NM_000839.5	NP_000830.2	metabotropic glutamate receptor 2 isoform a precursor
XM_024453490.2	XP_024309258.1	metabotropic glutamate receptor 2 isoform X7
XM_047448051.1	XP_047304007.1	metabotropic glutamate receptor 2 isoform X4
NM_001349116.2	NP_001336045.1	metabotropic glutamate receptor 2 isoform c
NM_001349117.2	NP_001336046.1	metabotropic glutamate receptor 2 isoform d
XM_011533643.2	XP_011531945.1	metabotropic glutamate receptor 2 isoform X6
XM_047448050.1	XP_047304006.1	metabotropic glutamate receptor 2 isoform X4
XM_011533642.2	XP_011531944.1	metabotropic glutamate receptor 2 isoform X5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18297054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRM2 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
872 a.a.

Protein Preferred Names	Protein Names
metabotropic glutamate receptor 2	glutamate receptor homolog glutamate receptor, metabotropic 2

GRM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GRM2	Q14416	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	GRM2	Q14416	NAALADL2	Homo sapiens	Q58DX5	Y2H Prey Pooling	25416956
Intra	GRM2	Q14416	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	GRM2	Q14416	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	GRM2	Q14416	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	GRM2	Q14416	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	GRM2	Q14416	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	GRM2	Q14416	ACBD5	Homo sapiens	Q5T8D3-2	Validated Y2H	32296183
Intra	GRM2	Q14416	ACBD5	Homo sapiens	Q5T8D3-2	Y2H Array	32296183
Intra	GRM2	Q14416	ACBD5	Homo sapiens	Q5T8D3-2	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	GRM2	Q14416	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	GRM2	Q14416	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	GRM2	Q14416	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	GRM2	Q14416	HTR2A	Homo sapiens	P28223-1	Anti Bait CoIP	18297054
Intra	GRM2	Q14416	HTR2A	Homo sapiens	P28223-1	Anti Tag CoIP	18297054
Intra	GRM2	Q14416	TSPAN18	Homo sapiens	Q8WUV1	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	TSPAN18	Homo sapiens	Q8WUV1	Validated Y2H	32296183
Intra	GRM2	Q14416	TSPAN18	Homo sapiens	Q8WUV1	Y2H Array	32296183
Intra	GRM2	Q14416	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	GRM2	Q14416	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	GRM2	Q14416	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	CLDN9	Homo sapiens	O95484	Y2H Array	32296183
Intra	GRM2	Q14416	CLDN9	Homo sapiens	O95484	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	TMEM130	Homo sapiens	Q8N3G9	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	TMEM130	Homo sapiens	Q8N3G9	Y2H Array	32296183
Intra	GRM2	Q14416	TMEM130	Homo sapiens	Q8N3G9	Validated Y2H	32296183
Cross	GRM2	Q14416	S	SARS-CoV-2	P0DTC2	Pull Down	34903715
Cross	GRM2	Q14416	S	SARS-CoV-2	P0DTC2	Anti Tag CoIP	34903715
Intra	GRM2	Q14416	DPP4	Homo sapiens	P27487	Anti Tag CoIP	34903715
Intra	GRM2	Q14416	DPP4	Homo sapiens	P27487	Pull Down	34903715
Intra	GRM2	Q14416	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	GRM2	Q14416	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	GRM2	Q14416	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	GRM2	Q14416	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	GRM2	Q14416	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	GRM2	Q14416	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	GRM2	Q14416	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	GRM2	Q14416	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	GRM2	Q14416	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	GRM2	Q14416	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	CLDN2	Homo sapiens	P57739	Y2H Array	32296183
Intra	GRM2	Q14416	CLDN2	Homo sapiens	P57739	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	ACE2	Homo sapiens	Q9BYF1	Anti Tag CoIP	34903715
Intra	GRM2	Q14416	ACE2	Homo sapiens	Q9BYF1	Pull Down	34903715
Intra	GRM2	Q14416	CCDC107	Homo sapiens	Q8WV48	Validated Y2H	32296183
Intra	GRM2	Q14416	CCDC107	Homo sapiens	Q8WV48	Y2H Array	32296183
Intra	GRM2	Q14416	CCDC107	Homo sapiens	Q8WV48	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	SLC38A1	Homo sapiens	Q9H2H9	Y2H Prey Pooling	32296183
Intra	GRM2	Q14416	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183
Intra	GRM2	Q14416	SLC38A1	Homo sapiens	Q9H2H9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GRM2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83473	Metabotropic Glutamate Receptor 2 Antibody (YA3218)	WB, IHC-P	Human, Mouse
HY-P83473A	Metabotropic Glutamate Receptor 2 Antibody (YA3218)(PBS only)	WB, IHC-P	Human, Mouse
HY-P84569	Metabotropic Glutamate Receptor 2 Antibody (YA4266)	WB, FC, ELISA	Human
HY-P84569A	Metabotropic Glutamate Receptor 2 Antibody (YA4266)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Cocaine Dependence
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Allergic Urticaria
Mental Depression	Depression Depressive Disorder
Substance Dependence
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Generalized Anxiety Disorder	Anxiety Generalized
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Central Nervous System Disease	CNS Cns Diseases Central Nervous System Diseases Cns Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05822	GRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05823	Grm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05824	Grm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GRM2	RGD	RGD:2743
Macaca mulatta	GRM2	VGNC	VGNC:73286
Bos taurus	GRM2	VGNC	VGNC:29659
Mus musculus	GRM2	MGD	MGI:1351339
Canis familiaris	GRM2	VGNC	VGNC:41509
Felis catus	GRM2	VGNC	VGNC:67477
Others	GRM2	NCBI