PIK3CB - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

Also Known as PI3K; PIK3C1; P110BETA; PI3KBETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5291

About PIK3CB

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,652,698-138,834,928 (from NCBI)

This gene has 14 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 97 phenotypes. Ubiquitous expression in thyroid (RPKM 19.2), kidney (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or Infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

PIK3CB Products (14)

mRNA	Protein	Name
XM_047448315.1	XP_047304271.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X3
XM_047448310.1	XP_047304266.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448313.1	XP_047304269.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_047448311.1	XP_047304267.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_011512895.3	XP_011511197.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
NM_001256045.2	NP_001242974.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 2
XM_017006619.2	XP_016862108.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448314.1	XP_047304270.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_006713659.4	XP_006713722.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448307.1	XP_047304263.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448312.1	XP_047304268.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
XM_047448308.1	XP_047304264.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
XM_047448309.1	XP_047304265.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
NM_006219.3	NP_006210.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	12502714	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	25327288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19380743	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	12502714	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	30496354	GOA
involved in negative regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	30496354	GOA
involved in negative regulation of vascular endothelial growth factor signaling pathway	IGI IGI: Inferred from genetic interaction	30496354	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	30496354	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18558630	GOA
involved in phosphatidylinositol phosphate biosynthetic process	IDA IDA: Inferred from direct assay	12502714	GOA
acts upstream of or within phosphorylation	IDA IDA: Inferred from direct assay	25327288	GOA
involved in positive regulation of Rac protein signal transduction	IGI IGI: Inferred from genetic interaction	18558630	GOA
involved in positive regulation of endothelial cell migration	IGI IGI: Inferred from genetic interaction	18558630	GOA
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25139353	GOA
involved in positive regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	25339672	GOA
acts upstream of or within positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	18558630	GOA
acts upstream of or within regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	25139353	GOA
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18558630	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	30496354	GOA
part of phosphatidylinositol 3-kinase complex, class IA	IPI IPI: Inferred from physical interaction	20713702	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3CB Protein Structure

PI3K_p85B

PI3K_rbd

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
200
400
600
800
1000
1070 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PI3-kinase p110 subunit beta PI3-kinase subunit beta PI3K-beta PtdIns-3-kinase p110 phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta phosphoinositide-3-kinase, catalytic, beta polypeptide ptdIns-3-kinase subunit beta ptdIns-3-kinase subunit p110-beta serine/threonine protein kinase PIK3CB

PIK3CB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PIK3CB	P42338	PIK3R2	Homo sapiens	O00459	Pull Down	32707033
Intra	PIK3CB	P42338	PIK3R1	Homo sapiens	P27986	Anti Tag CoIP	33961781
Intra	PIK3CB	P42338	PIK3R1	Homo sapiens	P27986	Pull Down	32707033
Intra	PIK3CB	P42338	PIK3R3	Homo sapiens	Q92569	Y2H Array	25814554
Intra	PIK3CB	P42338	PIK3R1	Homo sapiens	P27986-2	BFG-2H	27107012
Intra	PIK3CB	P42338	PIK3R1	Homo sapiens	P27986-2	Validated Y2H	27107012
Intra	PIK3CB	P42338	PIK3R1	Homo sapiens	P27986-2	Y2H	27107012

Cross: Cross-species interaction Intra: Intraspecies interaction

PIK3CB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81211	phospho-PI3 Kinase p110 beta (Ser1070) Antibody	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
HY-P86116	PI3-Kinase p110 β Antibody (YA5808)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Immunodeficiency 14	Activated Pi3k-Delta Syndrome Apds Pasli Disease Imd14 Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi	Cloves Syndrome Clove Syndrome Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities Clove Syndrome, Somatic Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome CLOVE Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities Congenital Arteriovenous Malformation Arteriovenous Hemangioma Nevus Melanocytic Nevus Benign Melanocytic Nevus
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Cowden Syndrome 1	Pten Hamartoma Tumor Syndrome Bannayan-Riley-Ruvalcaba Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Lhermitte-Duclos Syndrome Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Adenosquamous Prostate Carcinoma	Adenosquamous Carcinoma Of Prostate Adenosquamous Carcinoma Of The Prostate
Breast Juvenile Papillomatosis	Juvenile Papillomatosis Of The Breast
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Nk-Cell Enteropathy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-126077	MTI-31	Inhibitor	99.98%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10526	PIK3CB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10527	Pik3cb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10528	PIK3CB Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIK3CB	MGD	MGI:1922019
Macaca mulatta	PIK3CB	VGNC	VGNC:75996
Rattus norvegicus	PIK3CB	RGD	RGD:620917
Canis familiaris	PIK3CB	VGNC	VGNC:44556
Bos taurus	PIK3CB	VGNC	VGNC:32890
Felis catus	PIK3CB	VGNC	VGNC:68855
Others	PIK3CB	NCBI