Nelutroctiv
Based on 1 Customer Validation
Nelutroctiv (CK-136) is an orally active and selective cardiac troponin activator. Nelutroctiv activates cardiac sarcomeres by enhancing the sensitivity of troponin to calcium ions and promoting the interaction between actin and myosin. Nelutroctiv enhances cardiac contractility. Nelutroctiv can be used in the researches for cardiovascular diseases with impaired cardiac contractile function.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 2299177-09-4
- Formula: C24H22F5N3O4S
- Molecular Weight:543.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Calcium Channel Isoforms
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Biological Activity
Nelutroctiv (1 μM) reduces the calcium concentration for 50% maximum tension (EC50) by 16%-25% and increases maximum tension (Tmax) by 16%-50% in permeabilized myocytes from human HFrEF, HFpEF (with or without severe obesity)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2299177-09-4
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Appearance Solid
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Molecular Weight 543.51
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Formula C24H22F5N3O4S
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Color White to off-white
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SMILES
O=C(C1=CN=CC(S(C)(=O)=O)=C1)N2[C@@]3([H])[C@](C[C@@H]2C(N[C@H](C4CC4)C5=C(C=C(C(F)=C5)C(F)(F)F)F)=O)([H])C3
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Synonyms
CK-136
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (183.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8399 mL | 9.1995 mL | 18.3989 mL | 45.9973 mL |
| 5 mM | 0.3680 mL | 1.8399 mL | 3.6798 mL | 9.1995 mL | |
| 10 mM | 0.1840 mL | 0.9199 mL | 1.8399 mL | 4.5997 mL | |
| 15 mM | 0.1227 mL | 0.6133 mL | 1.2266 mL | 3.0665 mL | |
| 20 mM | 0.0920 mL | 0.4600 mL | 0.9199 mL | 2.2999 mL | |
| 25 mM | 0.0736 mL | 0.3680 mL | 0.7360 mL | 1.8399 mL | |
| 30 mM | 0.0613 mL | 0.3066 mL | 0.6133 mL | 1.5332 mL | |
| 40 mM | 0.0460 mL | 0.2300 mL | 0.4600 mL | 1.1499 mL | |
| 50 mM | 0.0368 mL | 0.1840 mL | 0.3680 mL | 0.9199 mL | |
| 60 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7666 mL | |
| 80 mM | 0.0230 mL | 0.1150 mL | 0.2300 mL | 0.5750 mL | |
| 100 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4600 mL |
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