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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
20-lyase
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "20-lyase" in MCE Product Catalog:
24
Target:
Research Areas:
Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.
2
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Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4 .
Cat. No.: HY-70013S
CAS No.: 2122245-62-7
Synonyms: CB-7598-d4
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4-Pyridylmethyl adamantanecarboxamide (Compound 11) is an Aromatase inhibitor with an IC50 of 1.5 μM against hAromatase. 4-Pyridylmethyl adamantanecarboxamide inhibits the C17,20-lyase activity of testicular cytochrome P45017α with an IC50 of 1600 nM, and also inhibits the 17α-hydroxylase activity of this enzyme with an IC50 of 7700 nM. 4-Pyridylmethyl adamantanecarboxamide can be used in the research of prostate cancer .
Cat. No.: HY-120067
CAS No.: 183012-13-7
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YM116 is an orally active and competitive CYP17A1 (17,20-lyase) inhibitor (Ki: 0.38 nM). YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity. YM116 decreases the serum testosterone concentration, reduces dehydroepiandrosterone sulfate levels and decreases prostatic weights .
Cat. No.: HY-70013R
CAS No.: 154229-19-3
Synonyms: CB-7598 (Standard)
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Research Areas:
Abiraterone (Standard) is the analytical standard of Abiraterone. This product is intended for research and analytical applications. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.
Cat. No.: HY-E71368
Target:
Research Areas:
17α-Hydroxyprogesterone deacetylase (EC 1.14.14.32) is a cytochrome P450 enzyme that exhibits 17,20-lyase activity. It participates in catalyzing the 17-hydroxylation of pregnenolone and progesterone.
Cat. No.: HY-P85566
Synonyms: 20 lyase; CP17A_HUMAN; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome P450 family 17; Cytochrome P450 family 17 subfamily A polypeptide 1; Cytochrome p450 subfamily XVII; steroid 17 alpha hydroxylase; adrenal hyperplasia; Cytochrome p450 XVIIA1; Cytochrome P450-C17; Cytochrome P450c17; OTTHUMP00000020382; P450 C17; P450c17; S17AH; Steroid 17 alpha hydroxylase/17,20 lyase; Steroid 17 alpha monooxygenase; Steroid 17-alpha-hydroxylase/17; Steroid 17-alpha-monooxygenase.
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(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime is a human 17α-hydroxylase/C17,20-lyase (P45017α) inhibitor with a human IC50 of 67 nM and a rat IC50 of 2754 nM. (3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime blocks the human testicular microsomal enzyme mediating androgen biosynthesis steps. (3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime does not inhibit human 5α-reductase in prostatic microsomes .
Cat. No.: HY-10505R
CAS No.: 566939-85-3
Synonyms: TAK-700 (Standard)
Target:
Research Areas:
Orteronel (Standard) is the analytical standard of Orteronel (HY-10505). This product is intended for research and analytical applications. Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4 .
Cat. No.: HY-136745
CAS No.: 331684-05-0
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Research Areas:
Aromatase-IN-1 is a competitive aromatase (P450arom) inhibitor with a human IC50 of 40 nM and a Ki of 1.05 nM. Aromatase-IN-1 binds via coordination of imidazole nitrogen to the heme iron of aromatase. Aromatase-IN-1 can be used for the research of breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
