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Cat. No.: HY-Z14322

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(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime

(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime is a human 17α-hydroxylase/C17,20-lyase (P450₁₇α) inhibitor with a human IC₅₀ of 67 nM and a rat IC₅₀ of 2754 nM. (3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime blocks the human testicular microsomal enzyme mediating androgen biosynthesis steps. (3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime does not inhibit human 5α-reductase in prostatic microsomes.

For research use only. We do not sell to patients.

CAS No.: 2174-13-2
Formula: C₂₃H₃₃NO₃
Molecular Weight:371.52

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Please store the product under the recommended conditions in the Certificate of Analysis.

(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime Chemical Structure

CAS No.: 2174-13-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

In Vitro

(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime (150 nM; 60 min) potently inhibits human testicular microsomal 17α-hydroxylase/C₁₇,₂₀-lyase with an IC₅₀ of 67 nM^[1].
(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime (1500 nM; 60 min) weakly inhibits rat testicular microsomal C₁₇,₂₀-lyase with an IC₅₀ of 2754 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2174-13-2
Molecular Weight 371.52
Formula C₂₃H₃₃NO₃
SMILES

C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)C(C(=NO)C)=CC4)[H])(CC=C1C[C@@H](OC(C)=O)CC2)[H])[H]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ling Y, et al. Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/C17, 20-lyase and 5α-reductase[J]. Bioorganic & medicinal chemistry, 1998, 6(10): 1683-1693.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime

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(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(3β)-3-(Acetyloxy)pregna-5,16-dien-20-one 20-oxime Related Classifications

HY-Z14322 Related Classifications

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