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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
AAV
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "AAV" in MCE Product Catalog:
1
1 Cited Publications
Art. -Nr.: HY-P990181
Target:
Forschungsgebiete:
Art. -Nr.: HY-177022
CAS. Nr.: 2495324-66-6
ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB) .
Synonyms: RO7020531; RG7854
Target:
Forschungsgebiete:
Ruzotolimod (RO7020531) is an orally active TLR7 agonist. Ruzotolimod inhibits WHV viral replication and, in combination with RO-7049389 (HY-145579), inhibits AAV-HBV viral load. Ruzotolimod can be used to study infection with COVID-19 or SARS-CoV-2 .
Art. -Nr.: HY-P10535
CAS. Nr.: 872141-81-6
Art. -Nr.: HY-174819
CAS. Nr.: 2396680-45-6
VNRX-9945 is a potent, broadly and orally active HBV CAM (capsid assembly modulator) with an EC50 of 2.6 nM. VNRX-9945 exhibits excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. VNRX-9945 demonstrates robust antiviral efficacy in the adeno-associated virus mice models of HBV (AAV-HBV) infection .
Art. -Nr.: HY-P5496
CAS. Nr.: 872141-80-5
Art. -Nr.: HY-177300
CAS. Nr.: 1402802-45-2
Forschungsgebiete:
TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM). TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus .
Art. -Nr.: HY-149357
CAS. Nr.: 2569526-80-1
Yhhu6669 is an anti-HBV agent. Yhhu6669 inhibits HBV DNA. Yhhu6669 inhibits HBV replication by inducing the formation of DNA-free capsids. Yhhu6669 decreases HBV DNA and HBcAg in AAV/HBV-infected mice. Yhhu6669 has favorable PK properties .
Art. -Nr.: HY-P992154
Synonyms: KJ-103
Forschungsgebiete:
Art. -Nr.: HY-49538C
CAS. Nr.: 1246958-42-8
Target:
Forschungsgebiete:
ASP7967 hemifumarate is an orally active ligand of the RNA aptamer AC17-4 with a Kd of 12 nM. ASP7967 hemifumarate binds AC17-4 to regulate aptazyme-based and exon-skipping riboswitches, thereby enabling small-molecule-controlled transgene expression without exogenous protein factors. ASP7967 hemifumarate can be used for the study of synthetic RNA switches, gene expression regulation and AAV-based gene therapy-related expression control .
Art. -Nr.: HY-P76445
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Influenza A H16N3 (A/black-headed gull/Sweden/5/99) Hemagglutinin / HA Protein (His)
Species:
Source:
Art. -Nr.: HY-P75136
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Influenza A H13N8 (A/black-headed gull/Netherlands/1/00) Hemagglutinin / HA Protein (His)
Species:
Source:
Art. -Nr.: HY-P76444
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Influenza A H13N6 (A/black-headed gull/Sweden/1/1999) Hemagglutinin / HA Protein (His)
Species:
Source:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
