1948241-60-8
Chemical Structure
Ruzotolimod
Synonym(s): RO7020531; RG7854
- CAS No.: 1948241-60-8
- Formula:C14H18N4O5S
- Molecular Weight:354.38
IUPAC Name: (S)-1-((2S,4R,5R)-5-(5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl)-4-hydroxytetrahydrofuran-2-yl)propyl acetate
InChIKey: OJEUDXXMKNXHST-JDVQERKKSA-N
SMILES: O=C1N([C@]([C@@H](C2)O)([H])O[C@]2([H])[C@H](CC)OC(C)=O)C3=NC(N)=NC=C3S1
Biological Activity: Ruzotolimod (RO7020531) is an orally active TLR7 agonist. Ruzotolimod inhibits WHV viral replication and, in combination with RO-7049389 (HY-145579), inhibits AAV-HBV viral load. Ruzotolimod can be used to study infection with COVID-19 or SARS-CoV-2[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ruzotolimod | 99.92% | Ruzotolimod (RO7020531) is an orally active TLR7 agonist. Ruzotolimod inhibits WHV viral replication and, in combination with RO-7049389 (HY-145579), inhibits AAV-HBV viral load. Ruzotolimod can be used to study infection with COVID-19 or SARS-CoV-2. | ||||||||||||||||||||
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- [1]. Qingyan BO, et al. Method of treating virus infection using a tlr7 agonist. Patent WO2021130195A1.
- [2]. Jiang Q, et al. Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like receptor 7 agonist ruzotolimod[J]. Clinical and Translational Science, 2024, 17(8): e13896. [Content Brief]
- [3]. Croasdell G. European Association for the Study of the Liver-53rd International Liver Congress. Paris, France-April 11-15, 2018. Drugs of the Future, 2018, 43(7).
- [4]. Wildum S, et al. Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B. Front Immunol. 2022 May 23;13:884113. [Content Brief]
Keywords
