3 Results for "

Arnebin

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Arnebin" in MCE Product Catalog:

3
β,β-Dimethylacrylalkannin
β,β-Dimethylacrylalkannin
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3 Cited Publications
Cat. No.: HY-N5112A
CAS No.: 34539-65-6
Synonyms: Arnebin 1
Category:  

Quinones other families Other Diseases Plants Disease Research Fields Naphthalene Quinones Pteris livida Mett.

Target:  

FGFR Necroptosis Apoptosis CDK JNK

β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .
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(Rac)-Arnebin 1
(Rac)-Arnebin 1
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Cat. No.: HY-N5112
CAS No.: 5162-01-6
Synonyms: (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-​Dimethylacrylshikonin
Category:  

Quinones Other Diseases Phenols Polyphenols Plants Lithospermum canescens Lehm. Disease Research Fields Boraginaceae Naphthalene Quinones

Target:  

HIF/HIF Prolyl-Hydroxylase

(Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity .
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β,β-Dimethylacrylalkannin (Standard)
β,β-Dimethylacrylalkannin (Standard)
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Cat. No.: HY-N5112AR
CAS No.: 34539-65-6
Synonyms: Arnebin 1 (Standard)
Category:  

Quinones other families Plants Naphthalene Quinones Pteris livida Mett.

Target:  

Reference Standards HIF/HIF Prolyl-Hydroxylase

β,β-Dimethylacrylalkannin (Standard) (Arnebin 1 (Standard)) is the analytical standard of β,β-Dimethylacrylalkannin (HY-N5112A). This product is intended for research and analytical applications. β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells .
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