Aspartame

By Targets:	Angiotensin-converting Enzyme (ACE) (2) Apoptosis (3) Biochemical Assay Reagents (2) Drug Derivative (5) Drug Intermediate (1) Drug Metabolite (3) Environmental Pollutants (1) Isotope-Labeled Compounds (3) Reference Standards (5) Taste Receptor (5)
By Research Areas:	Cardiovascular Disease (2) Metabolic Disease (4) Neurological Disease (5)
Oligonucleotides:	Sweetening Agents (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0361

*Aspartame* 1 Publications Verification SC-18862	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-W011053

Neotame	Taste Receptor Apoptosis Drug Derivative	Metabolic Disease
Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

HY-122351A

Advantame	Taste Receptor	Others
Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K ⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .

HY-23093

L-Aspartyl-L-phenylalanine	Angiotensin-converting Enzyme (ACE) Drug Metabolite	Cardiovascular Disease
L-Aspartyl-L-phenylalanine is a metabolite of aspartame that can inhibit angiotensin converting enzyme (ACE) purified from rabbit lungs with a K_i of 11 μM .

HY-B0361R

Aspartame (Standard) SC-18862 (Standard)	Biochemical Assay Reagents Reference Standards	Neurological Disease
Aspartame (Standard) is the analytical standard of Aspartame. This product is intended for research and analytical applications. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-W009426

Cyclo(Phe-Asp)	Drug Intermediate	Others
Cyclo(Phe-Asp) is an Aspartame (HY-B0361) impurity.

HY-B0361S1

Aspartame-d5	Isotope-Labeled Compounds	Neurological Disease
Aspartame-d₅ is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) .

HY-B0361S

Aspartame-d3 SC-18862-d₃	Isotope-Labeled Compounds	Neurological Disease
Aspartame-d₃ is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) .

HY-W011053GL

Neotame (GMP Like)	Taste Receptor Apoptosis Drug Derivative	Metabolic Disease
Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

HY-23093R

L-Aspartyl-L-phenylalanine (Standard)	Reference Standards Angiotensin-converting Enzyme (ACE) Drug Metabolite	Cardiovascular Disease
L-Aspartyl-L-phenylalanine (Standard) is the analytical standard of L-Aspartyl-L-phenylalanine. This product is intended for research and analytical applications. L-Aspartyl-L-phenylalanine is a metabolite of aspartame that can inhibit angiotensin converting enzyme (ACE) purified from rabbit lungs with a Ki of 11 μM .

HY-122351

Advantame free acid	Drug Derivative Taste Receptor	Others
Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K ⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .

HY-131280R

Devaleryl Valsartan Impurity (Standard)	Drug Metabolite Reference Standards	Others
L-Aspartyl-L-phenylalanine (Standard) is the analytical standard of L-Aspartyl-L-phenylalanine. This product is intended for research and analytical applications. L-Aspartyl-L-phenylalanine is a metabolite of aspartame that can inhibit angiotensin converting enzyme (ACE) purified from rabbit lungs with a Ki of 11 μM .

HY-W011053S

(R)-Neotame-d3	Isotope-Labeled Compounds	Others
(R)-Neotame-d₃ is the deuterium labeled Neotame. Neotame is a derivative of Aspartame and is a low-caloric and high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame is a non-nutritive sweetener and flavor enhancer that can be used in a variety of foods .

HY-W011053R

Neotame (Standard)	Apoptosis Drug Derivative Reference Standards	Metabolic Disease
Neotame (Standard) is the analytical standard of Neotame (HY-W011053). This product is intended for research and analytical applications. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

HY-122351AR

Advantame (Standard)	Reference Standards Taste Receptor	Others
Advantame (Standard) is the analytical standard of Advantame. This product is intended for research and analytical applications. Advantame is an N-substituted derivative of aspartame. Advantame is a high-intensity, low calorie sweetener. Advantame can interact with plasma protein. Advantame has the potential to produce hypotension and inhibit hERG K ⁺ channel to produce carditoxicity. Advantame binds to T1R2/T1R3 taste GPCR to form an oligomeric functional selectivity of biased heteromers with NMBR to induce a significant sialidase activity in vitro. Advantame has maternal toxicity (gastrointestinal disturbances) in the prenatal developmental toxicity study in rabbits .

HY-167931

Cinnamohydrazide	Drug Derivative	Metabolic Disease
Cinnamohydrazide, an unsaturated carboxylic acid derivative, serves as a precursor to aspartame through enzyme-mediated amination to phenylalanine. This compound may offer potential benefits in the prevention and treatment of diabetes by facilitating insulin secretion, enhancing pancreatic β-cell function, inhibiting hepatic gluconeogenesis, promoting glucose uptake, amplifying insulin signaling pathways, delaying carbohydrate digestion and glucose absorption, and reducing protein glycation and insulin fibrillation.

Cat. No.	Product Name	Type

HY-W011053GL

Neotame (GMP Like)	Fluorescent Dyes
Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

Neotame (GMP Like)

Fluorescent Dyes

Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

Cat. No.	Product Name	Type

HY-W011053GL

Neotame (GMP Like)	Biochemical Assay Reagents
Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

Neotame (GMP Like)

Biochemical Assay Reagents

Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

Cat. No.	Product Name	Target	Research Area

HY-B0361

*Aspartame* 1 Publications Verification SC-18862	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-B0361R

Aspartame (Standard) SC-18862 (Standard)	Biochemical Assay Reagents Reference Standards	Neurological Disease
Aspartame (Standard) is the analytical standard of Aspartame. This product is intended for research and analytical applications. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-118347

Aspartame acesulfame	Peptides	Neurological Disease
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) .

HY-P4840

Ac-Phe-Lys-OH	Peptides	Others
Ac-Phe-Lys-OH is a inverted Aspartame type sweetener .

Cat. No.	Product Name	Chemical Structure

HY-B0361S1

Aspartame-d5
Aspartame-d₅ is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) .

HY-B0361S

Aspartame-d3
Aspartame-d₃ is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) .

HY-W011053S

(R)-Neotame-d3
(R)-Neotame-d₃ is the deuterium labeled Neotame. Neotame is a derivative of Aspartame and is a low-caloric and high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame is a non-nutritive sweetener and flavor enhancer that can be used in a variety of foods .

Cat. No.	Product Name		Classification

HY-B0361

*Aspartame* 1 Publications Verification SC-18862		Sweetening Agents
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011053GL

Neotame (GMP Like)	Taste Receptor Apoptosis Drug Derivative	Metabolic Disease
Neotame (GMP Like) is the GMP Like class Neotame (HY-W011053) that can be used as pharmaceutical excipients. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

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