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BGT-1

" in MedChemExpress (MCE) Product Catalog:

13

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製品番号 製品名 Target 研究分野 構造式
  • HY-103509
    NNC 05-2090 hydrochloride

    		GABA Receptor Neurological Disease
    NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases [1] .
    NNC 05-2090 hydrochloride
  • HY-119591
    BPDBA

    		GABA Receptor Neurological Disease
    BPDBA is a selective and noncompetitive betaine/GABA transporter (BGT-1) inhibitor with IC50s of 20 μM and 35 μM against human BGT-1 and mouse GAT2, respectively [1].
    BPDBA
  • HY-N2482A
    Guvacine hydrobromide
    1 Publications Verification

    		 GABA Receptor Neurological Disease
    Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively [1].
    Guvacine hydrobromide
  • HY-124285
    ATPCA hydrochloride

    		GABA Receptor Others
    ATPCA hydrochloride is a selective radioactive substrate for BGT1 over GAT1/GAT3 [1].
    ATPCA hydrochloride
  • HY-N2482
    Guvacine

    		GABA Receptor Neurological Disease
    Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively [1].
    Guvacine
  • HY-118931
    EF-1502

    		GABA Receptor Neurological Disease
    EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy [1].
    EF-1502
  • HY-W033027
    BGT1-IN-1

    		GABA Receptor Neurological Disease
    BGT1-IN-1 (compound 9) is a potent BGT1 inhibitor with IC50 value of 13.9, 58.3 µM for hBGT1, GAT3, respectively. BGT1-IN-1 shows no cytotoxic. BGT1-IN-1 shows neuroprotective activity [1].
    BGT1-IN-1
  • HY-120146
    NNC 05-2090

    		GABA Receptor Neurological Disease
    NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50 sub>: 10.6 μM). NNC 05-2090 also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases [1] .
    NNC 05-2090
  • HY-RS13298
    SLC6A12 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SLC6A12 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SLC6A12 Human Pre-designed siRNA Set A
    SLC6A12 Human Pre-designed siRNA Set A
  • HY-182944
    GATT-44

    		GABA Receptor Neurological Disease
    GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC50 of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated 18F-radiofluorination. The radiolabeled GATT-44 ([ 18F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases [1].
    GATT-44
  • HY-181135
    Bicyclo-GABA

    		GABA Receptor Neurological Disease
    Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC50 of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α1β2γ2 GABAA receptors with an EC50 of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery [1].
    Bicyclo-GABA
  • HY-103509R
    NNC 05-2090 hydrochloride (Standard)

    		Reference Standards GABA Receptor Neurological Disease
    NNC 05-2090 hydrochloride (Standard) is the analytical standard of NNC 05-2090 hydrochloride (HY-103509). This product is intended for research and analytical applications. NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases [1] .
    NNC 05-2090 hydrochloride (Standard)
  • HY-181753
    INSP-0154

    		Creatine Kinase Amino acid Transporter Inflammation/Immunology Cancer
    INSP-0154 is a potent creatine kinase B (CKB)/creatine transporter (SLC6A8) inhibitor. INSP-0154 binds to the SLC6A8 occluded pocket, prevents creatine transport into cells, and protects SLC6A8 cysteine residue C144 from irreversible inactivation. INSP-0154 inhibits creatine uptake in mouse heart tissue. INSP-0154 can be used for the research of cancer [1].
    INSP-0154

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