1265900-99-9
Chemical Structure
GATT-44
- CAS No.: 1265900-99-9
- Formula:C23H26FNO2
- Molecular Weight:367.46
InChIKey: XZCPNRFCLBNHOY-BAOGCXAUSA-N
SMILES: FC1=C(/C(C2=CC=CC=C2C)=C/CCN3C[C@@H](CCC3)C(O)=O)C=CC=C1
Biological Activity: GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC50 of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated 18F-radiofluorination. The radiolabeled GATT-44 ([18F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases[1].
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GATT-44 | GATT-44 is a blood-brain barrier-permeable, selective GABA transporter 1 (GAT-1) ligand with an IC50 of 126 nM. GATT-44 shows selectivity for GAT-2, GAT-3 and BGT-1 subtypes, and undergoes copper-mediated 18F-radiofluorination. The radiolabeled GATT-44 ([18F]GATT-44) exhibits brain uptake, metabolic stability and high GAT-1 binding specificity in non-human primates. GATT-44 is applicable for research on neurodegenerative and neuropsychiatric diseases. | |||||||||||||||||||||
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Keywords
