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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
BMPR2 kinase
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "BMPR2 kinase" in MCE Product Catalog:
Cat. No.: HY-164145
CAS No.: 3034216-44-6
Target:
CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway .
Cat. No.: HY-154970A
Purity: 99.40%
Target:
Research Areas:
BMPR2-IN-1 TFA is a selective BMPR2 inhibitor with a human BMPR2 IC50 of 506 nM and a Kd of 83.5 nM. BMPR2-IN-1 TFA functions as an ATP mimetic, forming hydrogen bonds with the BMPR2 kinase domain backbone and hydrophobic interactions with specific residues, and demonstrates high selectivity for BMPR2 over other kinases.BMPR2-IN-1 TFA can be used for the researches of cancer, pulmonary arterial hypertension and Alzheimer’s disease .
Cat. No.: HY-171247
CAS No.: 3034215-91-0
Target:
Research Areas:
CDD-1281 is a highly potent and selective BMPR2 kinase inhibitor with an IC50 of 1.2 nM. CDD-1281 can effectively inhibit BMP-mediated gene expression .
Cat. No.: HY-171248
CAS No.: 3034215-86-3
Research Areas:
CDD-1115 is a BMPR2 serine/threonine kinase inhibitor with an IC50 of 1.8 nM against human BMPR2 kinase. CDD-1115 selectively inhibits the catalytic activity of BMPR2, and shows weak inhibitory effects on ALK1 and ALK2 .
Cat. No.: HY-208727
CAS No.: 3034215-93-2
CDD-1282 is a non-inhibitor of bone morphogenetic protein receptor type 2 (BMPR2), with no functional inhibitory activity against BMPR2 kinase. CDD-1282 can serve as a negative control for BMPR2 inhibitors .
Cat. No.: HY-171249
CAS No.: 3034216-31-1
Target:
Research Areas:
CDD-1431 is a low-nanomolar selective kinase inhibitors of BMPR2, with Kiapp value of 20.6 nM. CDD-1431 suppresses BRE-reporter activity, with an IC50 of 4.87 μM. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation .
Cat. No.: HY-P7669
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like kinase; BRK-3; Primary Pulmonary Hyp
Cat. No.: HY-P703947
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like kinase; BRK-3; Primary Pulmonary Hyp
Cat. No.: HY-P72855
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like kinase; BRK-3; Primary Pulmonary Hyp
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
