BMPR-II Protein, Human (HEK293, hFc)
BMPR-II Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR-II protein, expressed by HEK293, with C-hFc tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
BMPR-II Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR-II protein, expressed by HEK293, with C-hFc tag.
Background
BMPR2 is a type II transmembrane serine/threonine kinase receptor that forms a complex with two type II and two type I receptors upon ligand binding. Type II receptors phosphorylate and activate type I receptors, which then autophosphorylate and recruit SMAD transcriptional regulators. It also mediates signaling via the p38MAPK cascade. BMPR2 binds to BMP7 and BMP2 (less efficiently to BMP4), with weak binding enhanced by the presence of BMP type I receptors. It mediates adipogenesis induction by GDF6 and promotes signaling through interaction with activin A/INHBA.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
Q13873-1 (S27-T150)
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Gene ID659
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Molecular Construction
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N-term
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BMPR-II (Ser27-Thr150)
Accession # Q13873-1 -
hFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
BMPR2; Bone Morphogenetic Protein Receptor Type-2; Prev. PPH1; BMP Type-2 Receptor; BMPR-II; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type II; Type II Activin Receptor-Like Kinase; BRK-3; Primary Pulmonary Hyp
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AA Sequence
SQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDET
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Predicted Molecular Mass
39.8 kDa
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Molecular Weight
Approximately 55-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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