3034215-86-3
3034215-86-3
Chemical Structure
CDD-1115
- CAS No.: 3034215-86-3
- Formula:C32H30N6O3
- Molecular Weight:546.62
InChIKey: UOCCUBNXBUXTNS-ZEQKJWHPSA-N
SMILES: NC(C1=CC=CC(CNC(C2=CC=C3N=C(C4=CC5=C(C=NC=C5)C=C4)N([C@H]6C[C@@H](CC6)C(NC)=O)C3=C2)=O)=C1)=O
Biological Activity: CDD-1115 is a BMPR2 serine/threonine kinase inhibitor with an IC50 of 1.8 nM against human BMPR2 kinase. CDD-1115 selectively inhibits the catalytic activity of BMPR2, and shows weak inhibitory effects on ALK1 and ALK2[1][2].
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CDD-1115 | CDD-1115 is a BMPR2 serine/threonine kinase inhibitor with an IC50 of 1.8 nM against human BMPR2 kinase. CDD-1115 selectively inhibits the catalytic activity of BMPR2, and shows weak inhibitory effects on ALK1 and ALK2. | |||||||||||||||||||||
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References
- [1]. Amrhein JA, et al. Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS medicinal chemistry letters. 2023 Jun 08;14(6):833-840. [Content Brief]
- [2]. Modukuri RK, et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. Journal of medicinal chemistry. 2023 Feb 09;66(3):2143-2160. [Content Brief]
Keywords
