![[D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14)](https://file.medchemexpress.com/product_pic/hy-p11408.gif "Click to View [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Bridge-helix
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Bridge-helix" in MCE Product Catalog:
Cat. No.: HY-P10654
CAS No.: 2861260-80-0
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Cat. No.: HY-P3314
CAS No.: 2251119-65-8
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Cat. No.: HY-P10819
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Cat. No.: HY-125442
CAS No.: 152340-22-2
Salinamide A is a bacterial RNA polymerase inhibitor with IC50: 0.2 μM against Staphylococcus aureus; 0.2 μM against Escherichia coli. Salinamide A inhibits transcription initiation and elongation, as well as bacterial RNA and protein synthesis without affecting DNA synthesis. Salinamide A can be used in studies related to the N-terminal hinge conformation and function of the RNAP bridge helix, and bacterial infections .
Cat. No.: HY-P11408
CAS No.: 349657-39-2
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Cat. No.: HY-184407
CAS No.: 1803030-41-2
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D-AAP1 is an RNA polymerase inhibitor. D-AAP1 exhibits anti-mycobacterial activity. D-AAP1 can be used for the research of mycobacterial infections .
Cat. No.: HY-184408
CAS No.: 3033990-94-9
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AAP-SO2 is a Bactericide and Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) inhibitor, with an IC50 of 0.025 μM against Mtb RNAP. AAP-SO2 allosterically slows the nucleotide addition rate during transcriptional elongation and enhances transcription termination efficiency. AAP-SO2 exhibits increased activity against β S450L-type Mtb, possesses activity against non-replicating Mtb, and shows whole-cell activity against Mtb and related mycobacterial species. AAP-SO2 reduces the overall emergence rate of Rifampicin (HY-B0272) tolerance in Mtb, alters the mutation spectrum, and decreases the proportion of β S450L-type Rifampicin-resistant mutants. AAP-SO2 acts synergistically with Rifampicin to kill non-replicating Mtb in a rabbit caseous necrosis model. AAP-SO2 can be used for the research of tuberculosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
