152340-22-2
Chemical Structure
Salinamide A
- CAS No.: 152340-22-2
- Formula:C51H69N7O15
- Molecular Weight:1020.13
IUPAC Name: (2R,3R)-N-((1'S,2S,4'R,4'S,7'R,10'S,13'R,14'S,Z)-4'-benzyl-17'-((S)-sec-butyl)-7'-((R)-1-hydroxyethyl)-3',4',13'-trimethyl-2',5',8',8',11',11',15',18'-octaoxospiro[oxirane-2,5'-112,3,12-trioxa-13,16,19,116,119,9-hexaaza-1(1,10)-cyclononadecana-2(1,4)-benzenacyclotridecaphanen]-6'-en-14'-yl)-3-hydroxy-2,4-dimethylpentanamide
InChIKey: UIHLRTKYJPYYEU-DOZJPHFESA-N
SMILES: C[C@H]([C@@]1(CO1)/C=C\C(NCC(OC[C@@]2(NC([C@]([H])(NC([C@@H](N3C)CC4=CC=CC=C4)=O)[C@@H](C)O)=O)[H])=O)=O)OC(C=C5)=CC=C5[C@@](NC(C([C@H](CC)C)NC([C@H]([C@H](OC2=O)C)NC([C@@H]([C@@H](C(C)C)O)C)=O)=O)=O)([H])C3=O
Biological Activity: Salinamide A is a bacterial RNA polymerase inhibitor with IC50: 0.2 μM against Staphylococcus aureus; 0.2 μM against Escherichia coli. Salinamide A inhibits transcription initiation and elongation, as well as bacterial RNA and protein synthesis without affecting DNA synthesis. Salinamide A can be used in studies related to the N-terminal hinge conformation and function of the RNAP bridge helix, and bacterial infections[1].
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Salinamide A | Salinamide A is a bacterial RNA polymerase inhibitor with IC50: 0.2 μM against Staphylococcus aureus; 0.2 μM against Escherichia coli. Salinamide A inhibits transcription initiation and elongation, as well as bacterial RNA and protein synthesis without affecting DNA synthesis. Salinamide A can be used in studies related to the N-terminal hinge conformation and function of the RNAP bridge helix, and bacterial infections. | |||||||||||||||||||||
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Keywords
