4 Results for "

C33A cells

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "C33A cells" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P10284
CAS No.: 853248-13-2
S7 is an inhibitory polypeptide targeting IL-6R, which specifically binds to IL-6R and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .
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Cat. No.: HY-168180
CAS No.: 2975172-98-4
Target:  

Wee1

Research Areas:  

Cancer

WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC50 of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC50s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively .
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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Cat. No.: HY-N15103
CAS No.: 178550-62-4
Target:  

Antibiotic HPV

Hydroxymycotrienin B is an ansamycin group antibiotic (triene-ansamycin) found in culture broths of Bacillus sp. BMJ958-62F4. Hydroxymycotrienin B inhibits HPV-positive cervical cancer cell growth 3~10 times more strongly than HPV-negative cervical cancer cells. Hydroxymycotrienin B can be used for the research of human cervical cancer .
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