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Results for "

CLIP tags

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (3) Drug Derivative (1) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (1) Fluorescent Dye (7)
By Research Areas:	Cancer (1) Infection (1) Neurological Disease (1)
Click Chemistry:	Azide (1) Tetrazine (1)

Inhibitors & Agonists

Fluorescent Dye

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101460

Tz-Thalidomide	E3 Ligase Ligand-Linker Conjugates Drug Derivative	Cancer
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a *CLIP-TAC* (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .

HY-D2956

BC-GLA-NHS CLIP-GLA-NHS	Biochemical Assay Reagents	Others
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-D2961

SiR-CLIP	Fluorescent Dye	Others
SiR-CLIP is a SiR-carboxyl derivative used for covalent fluorescent labeling of *CLIP* tags .

HY-D2946

CLIP-TMR BC-TMR	Fluorescent Dye	Infection
CLIP-TMR (BC-TMR) is a TMR-labeled CLIP tag fluorescent probe. CLIP-TMR combines the high specificity recognition ability of the CLIP-tag and the excellent optical performance of the TMR fluorophore, and can be used for the specific labeling and visualization of the HCV NS5A protein .

HY-D2960

BC-OG CLIP-OG	Fluorescent Dye	Others
BC-OG is an oregon green labeled CLIP tag fluorescent probe. BC-OG can be used for labeling CLIP-tag fusion protein in cells .

HY-D2954

BC-PEG-NH2 CLIP-PEG-NH2	Drug Intermediate	Others
BC-PEG-NH2 (CLIP-PEG-NH2) is a chemical building block specifically designed for the CLIP-tag system, featuring enhanced water solubility and reactivity. BC-PEG-NH2 can be used for the synthesis of super-resolution imaging probes .

HY-163327

pFBC	Biochemical Assay Reagents	Neurological Disease
pFBC ([ ¹⁸F]pEBC) is a covalent CLIP-tag radiotracer for detection of viral reporter gene transfer in the murine brain. pFBC can be used in neurobiological research .

HY-D2953

BC-CPY CLIP-CPY	Fluorescent Dye	Others
BC-CPY is a CLIP-tagged probe based on the pyridine-benzoanthrone (CPY) fluorophore (Ex/Em: 580 nm/610 nm). BC-CPY has excellent cell membrane permeability, enabling deep imaging, low phototoxicity and high signal-to-noise ratio. BC-CPY can be used for super-resolution microscopy imaging of living cells .

HY-D2945

CLIP-Biotin	Fluorescent Dye	Others
CLIP-Biotin is a Biotin-labeled CLIP tag fluorescent probe. CLIP-Biotin can be used for marking the CLIP-tag fusion proteins in cells.

HY-D2947

CLIP-505	Fluorescent Dye	Others
CLIP-505 is a CLIP-tag specific dye substrate. CLIP-505 is excited using either the 488 or 543 laser line .

HY-D2959

BC-DF CLIP-DF	Fluorescent Dye	Others
BC-DF is a diacetyl fluorescein labeled CLIP tag fluorescent probe. BC-DF can be used for labeling CLIP-tag fusion protein in cells .

HY-D2955

BC‐AZIDE CLIP-AZIDE	Biochemical Assay Reagents	Others
BC-AZIDE (CLIP-AZIDE) is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .

Cat. No.	Product Name	Type

HY-D2956

BC-GLA-NHS CLIP-GLA-NHS	Fluorescent Dye
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

BC-GLA-NHS

CLIP-GLA-NHS

Fluorescent Dye

BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-D2961

SiR-CLIP	Fluorescent Dye
SiR-CLIP is a SiR-carboxyl derivative used for covalent fluorescent labeling of *CLIP* tags .

HY-D2946

CLIP-TMR BC-TMR	Fluorescent Dye
CLIP-TMR (BC-TMR) is a TMR-labeled CLIP tag fluorescent probe. CLIP-TMR combines the high specificity recognition ability of the CLIP-tag and the excellent optical performance of the TMR fluorophore, and can be used for the specific labeling and visualization of the HCV NS5A protein .

HY-D2960

BC-OG CLIP-OG	Fluorescent Dye
BC-OG is an oregon green labeled CLIP tag fluorescent probe. BC-OG can be used for labeling CLIP-tag fusion protein in cells .

HY-D2954

BC-PEG-NH2 CLIP-PEG-NH2	Fluorescent Dye
BC-PEG-NH2 (CLIP-PEG-NH2) is a chemical building block specifically designed for the CLIP-tag system, featuring enhanced water solubility and reactivity. BC-PEG-NH2 can be used for the synthesis of super-resolution imaging probes .

HY-D2953

BC-CPY CLIP-CPY	Fluorescent Dye
BC-CPY is a CLIP-tagged probe based on the pyridine-benzoanthrone (CPY) fluorophore (Ex/Em: 580 nm/610 nm). BC-CPY has excellent cell membrane permeability, enabling deep imaging, low phototoxicity and high signal-to-noise ratio. BC-CPY can be used for super-resolution microscopy imaging of living cells .

HY-D2945

CLIP-Biotin	Fluorescent Dye
CLIP-Biotin is a Biotin-labeled CLIP tag fluorescent probe. CLIP-Biotin can be used for marking the CLIP-tag fusion proteins in cells.

HY-D2947

CLIP-505	Fluorescent Dye
CLIP-505 is a CLIP-tag specific dye substrate. CLIP-505 is excited using either the 488 or 543 laser line .

HY-D2959

BC-DF CLIP-DF	Fluorescent Dye
BC-DF is a diacetyl fluorescein labeled CLIP tag fluorescent probe. BC-DF can be used for labeling CLIP-tag fusion protein in cells .

HY-D2955

BC‐AZIDE CLIP-AZIDE	Fluorescent Dye
BC-AZIDE (CLIP-AZIDE) is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .

Cat. No.	Product Name		Classification

HY-101460

Tz-Thalidomide		Tetrazine
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a *CLIP-TAC* (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .

HY-D2955

BC‐AZIDE CLIP-AZIDE		Azide
BC-AZIDE (CLIP-AZIDE) is a nitrogen-functionalized protein labeling probe based on the CLIP-tag system. BC-AZIDE can be used for bioorthogonal click chemistry and intracellular orthogonal labeling .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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