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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
CLIP tags
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "CLIP tags" in MCE Product Catalog:
Research Areas:
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .
Cat. No.: HY-D2961
CAS No.: 1426090-10-9
Cat. No.: HY-D2946
Synonyms: BC-TMR
Cat. No.: HY-D2960
CAS No.: 1004524-78-0
Synonyms: CLIP-OG
Cat. No.: HY-D2954
CAS No.: 1108751-16-1
Synonyms: CLIP-PEG-NH2
Cat. No.: HY-163327
Target:
Research Areas:
pFBC ([ 18F]pEBC) is a covalent CLIP-tag radiotracer for detection of viral reporter gene transfer in the murine brain. pFBC can be used in neurobiological research .
Cat. No.: HY-D2953
Synonyms: CLIP-CPY
Cat. No.: HY-D2945
CAS No.: 1004524-73-5
Cat. No.: HY-D2955
CAS No.: 2432950-51-9
Synonyms: CLIP-AZIDE
Cat. No.: HY-D3589
CAS No.: 1151762-42-3
Target:
Research Areas:
BC-GLA is a benzylcytosine derivative conjugated with glutaric acid. BC-GLA is the acid form of BC-GLA-NHS. BC-GLA-NHS (CLIP-GLA-NHS) is an NHS-labeled CLIP tag, belonging to amine-reactive crosslinkers that enable site-specific protein labeling .
Cat. No.: HY-101460R
CAS No.: 2087490-42-2
Research Areas:
Tz-Thalidomide (Standard) is the analytical standard of Tz-Thalidomide (HY-101460). This product is intended for research and analytical applications. Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
