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Isoforms Recommended: CRY1
Results for "

CRY1

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148764
    M47

    		Cryptochrome Molecular Glues Apoptosis Cancer
    M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer [1].
    M47
  • HY-108468
    KL001
    2 Publications Verification

    		 Cryptochrome Metabolic Disease
    KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis [1] .
    KL001
  • HY-115672
    KS15
    3 Publications Verification

    		 Cryptochrome Cancer
    KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity [1] .
    KS15
  • HY-134194
    KL201
    2 Publications Verification

    		 Cryptochrome Metabolic Disease
    KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues [1].
    KL201
  • HY-RS03204
    CRY1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CRY1 Human Pre-designed siRNA Set A contains three designed siRNAs for CRY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CRY1 Human Pre-designed siRNA Set A
    CRY1 Human Pre-designed siRNA Set A
  • HY-134193
    KL101

    		Cryptochrome Metabolic Disease
    KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals [1].
    KL101
  • HY-136093B
    Lixumistat
    1 Publications Verification

    IM156 free base; HL156A free base; HL271 free base

    		 Mitochondrial Metabolism AMPK Neurological Disease Inflammation/Immunology
    Lixumistat (IM156 free base) is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis [1] .
    Lixumistat
  • HY-N10379
    19-epi-Scholaricine

    		Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related Inflammation/Immunology
    19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy [1] .
    19-epi-Scholaricine
  • HY-RS23225
    Cry1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cry1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cry1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cry1 Rat Pre-designed siRNA Set A
    Cry1 Rat Pre-designed siRNA Set A
  • HY-RS16785
    Cry1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cry1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cry1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cry1 Mouse Pre-designed siRNA Set A
    Cry1 Mouse Pre-designed siRNA Set A
  • HY-108468R
    KL001 (Standard)

    		Cryptochrome Reference Standards Metabolic Disease
    KL001 (Standard) is the analytical standard of KL001 (HY-108468). This product is intended for research and analytical applications. KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis [1] .
    KL001 (Standard)

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