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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
CRY1
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "CRY1" in MCE Product Catalog:
3
3 Cited Publications
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KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity [1] .
2
2 Cited Publications
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KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis [1] .
2
2 Cited Publications
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KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues [1].
1
1 Cited Publications
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M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer [1].
1
1 Cited Publications
Cat. No.: HY-136093B
CAS No.: 1422365-93-2
Synonyms: IM156 free base; HL156A free base; HL271 free base
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Lixumistat (IM156 free base) is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis [1] .
Cat. No.: HY-RS03204
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CRY1 Human Pre-designed siRNA Set A contains three designed siRNAs for CRY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-134193
CAS No.: 396721-89-4
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KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals [1].
Cat. No.: HY-N10379
CAS No.: 132923-06-9
Target:
Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related
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19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy [1] .
Cat. No.: HY-RS16785
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Cry1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cry1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23225
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Cry1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cry1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P7S0151
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRY1; CRYptochrome 1 (Photolyase-Like); Prev. PHLL1; DSPD; CRYptochrome-1; CRYptochrome Circadian Regulator 1; CRYptochrome Circadian Clock 1
Cat. No.: HY-108468R
CAS No.: 309928-48-1
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KL001 (Standard) is the analytical standard of KL001 (HY-108468). This product is intended for research and analytical applications. KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
