2. Apoptosis
  3. Apoptosis
  4. M47

M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer.

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M47 Chemical Structure

M47 Chemical Structure

CAS No. : 890808-56-7

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Based on 1 publication(s) in Google Scholar

M47 Related Antibodies

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Description

M47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].

In Vitro

M47 (0-10 μM; 0-120 h; U2OS Bmal1-dLuc cells) reduces the half-life of CRY1 in a dose-dependent manner and causes circadian changes[1].
M47 (10 μM; 24-44 h; U2OS cells) decreases the level of CRY1 in U2OS cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

M47 Related Antibodies

Western Blot Analysis[1]

Cell Line: U2OS cells
Concentration: 10 μM
Incubation Time: 24-44 hours
Result: Decreased CRY1 protein levels between 24 and 48 h.
In Vivo

M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6 J mice and p53 gene knockout C57BL/6 J mice) selectively reduces the half-life of CRY1 and is well tolerated with a good pharmacokinetic profile in vivo and enhances apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mice and p53 gene knockout C57BL/6 J mice[1]
Dosage: 5, 50, 300 and 1000 mg/kg
Administration: intraperitoneal injection, daily, for 5 days
Result: Prolonged the life span of p53 gene knockout mice.
Molecular Weight

471.93

Formula

C28H22ClNO4
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(N1C2=C(CC1)C=CC=C2)C(OC3=CC=C4OC(C)(C5)C6=CC=C(C=C6)Cl)=C(C)C3=C4C5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.90%

COA (250 KB) LCMS (153 KB)

Handling Instructions (2659 KB)
References
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M47 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M47890808-56-7M 47M-47ApoptosisCRY1nucleusdegradationcancerp53U2OS Bmal1-dLuc cellsInhibitorinhibitorinhibit

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