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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
CUL5
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "CUL5" in MCE Product Catalog:
Cat. No.: HY-RS03364
Target:
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CUL5 Human Pre-designed siRNA Set A contains three designed siRNAs for CUL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20711
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Cul5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cul5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27222
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Cul5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cul5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-169133
CAS No.: 2991588-80-6
Research Areas:
GDCNF-11 is a type of HSP90 interaction-mediated protein degradation chimera (HIM-PROTAC) degrader that targets and degrades GPX4, with a DC50 of 0.08 μM. GDCNF-11 mediates the ubiquitination and proteasome-dependent degradation of GPX4 by recruiting GPX4 to form a ternary complex with HSP90, increases intracellular lipid peroxides and ROS, and ultimately triggers Ferroptosis. GDCNF-11 inhibits tumor growth in mouse models, downregulates GPX4 protein in xenograft tumors, and upregulates the lipid peroxidation marker. GDCNF-11 can be used for the research of fibrosarcoma .
Cat. No.: HY-P702070
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CUL5; CULlin-5; CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1
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Cat. No.: HY-P702071
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CUL5; CULlin-5; CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1
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Source:
Cat. No.: HY-P703237
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VACM1
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Cat. No.: HY-P703238
Synonyms: VACM1
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Cat. No.: HY-P703239
Synonyms: VACM1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
