GDCNF-11
GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC50 value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526)).
(Pink: GPX4 ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: linker (HY-159772)).
For research use only. We do not sell to patients.
- CAS No.: 2991588-80-6
- Formula: C48H53Cl2N13O5S
- Molecular Weight:994.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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GPX4 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | IC50 |
0.74 μM
Compound: GDCNF-11
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Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human HT-1080 cells incubated for 48 hrs by CCK-8 assay
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[PMID: 39230973] |
| HT-1080 | IC50 |
35.5 μM
Compound: GDCNF-11
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Cytotoxicity against human HT-1080 cells incubated for 48 hrs in presence of Fer-1 by CCK-8 assay
Cytotoxicity against human HT-1080 cells incubated for 48 hrs in presence of Fer-1 by CCK-8 assay
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[PMID: 39230973] |
Chemical Information
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CAS No. 2991588-80-6
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Molecular Weight 994.99
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Formula C48H53Cl2N13O5S
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SMILES
NC1=NC(NCCC2CCN(CC2)C(CN3N=NC(COC4=C(C=C(C=C4)N(C(CCl)=O)C(C(NCCC5=CC=CC=C5)=O)C6=CC=CS6)Cl)=C3)=O)=C(C7=N1)N=CN7CC8=C(C(OC)=C(C=N8)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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