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Results for "

Calpain substrate

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Fluorescent Dyes

6

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1002
    Suc-Leu-Leu-Val-Tyr-AMC
    15+ Cited Publications

    Suc-LLVY-AMC

    		 Fluorescent Dye Proteasome Others
    Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .
    Suc-Leu-Leu-Val-Tyr-AMC
  • HY-13817
    IU1
    20+ Cited Publications

    		 Deubiquitinase Autophagy Apoptosis Cardiovascular Disease Neurological Disease Endocrinology Cancer
    IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
    IU1
  • HY-P4310
    Boc-Val-Leu-Lys-AMC

    		Ser/Thr Protease Others
    Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .
    Boc-Val-Leu-Lys-AMC
  • HY-P10050
    Calpain substrate

    		Proteasome Others
    Calpain substrate is the membrane non-permeable fluorogenic calpain substrate and can be used in Calpain enzymatic activity assay .
    Calpain substrate
  • HY-135172
    Suc-Leu-Tyr-AMC

    		Fluorescent Dye Others
    Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .
    Suc-Leu-Tyr-AMC
  • HY-DY1060
    Suc-Leu-Leu-Val-Tyr-AMC (solution)

    		Proteasome Fluorescent Dye Others
    Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) .
    Solvent and concentration: DMSO: 20 mM
    Suc-Leu-Leu-Val-Tyr-AMC (solution)
  • HY-P10073
    Calpain-1 substrate, fluorogenic

    		Fluorescent Dye Others
    Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)
    Calpain-1 substrate, fluorogenic

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