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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Calr
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Calr" in MCE Product Catalog:
2
2 Cited Publications
Research Areas:
Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer .
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Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) targeting HER3, consisting of the anti-HER3 IgG1 antibody Patritumab (HY-P99275), a cleavable tetrapeptide linker, and the membrane-permeable topoisomerase I (Topoisomerase Ⅰ) inhibitor DXd (HY-13631D). After binding to membrane-localized HER3, Patritumab deruxtecan is internalized into lysosomes, where the linker is cleaved to release DXd. DXd enters the nucleus to induce DNA damage and cell death, and exerts a bystander effect via transmembrane diffusion. Patritumab deruxtecan reduces the viability of HER3-positive cells and induces features of immunogenic cell death including CALR membrane exposure, ATP and HMGB1 release, and can be used in studies related to HER3-positive breast cancer and non-small cell lung cancer .
1
1 Cited Publications
Cat. No.: HY-P72112
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Calr; FLJ26680; Calreticulin; CRP55; Calregulin; ERp60; CC1qR; HACBP; Calr1; Grp60; SSA; Epididymis Secretory Sperm Binding Protein Li 99n; CRT; Autoantigen Ro; RO; HEL-S-99n; Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin); CRTC; Endoplasmic Reti
Cat. No.: HY-176252
CAS No.: 3055854-78-6
CALR ligand 1 (Compound 2a) is a calreticulin (CALR) ligand. CALR ligand 1 shows antitumor activity against triple-negative breast cancer (TNBC) cells (IC50=0.1 μM). CALR ligand 1 induces intracellular calcium overloading and triggers apoptosis in TNBC cells. CALR ligand 1 is promising for research of TNBC .
Cat. No.: HY-RS01847
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CALR Human Pre-designed siRNA Set A contains three designed siRNAs for CALR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01848
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CALR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CALR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20371
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Calr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Calr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17947
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Calr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Calr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24418
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Calr Rat Pre-designed siRNA Set A contains three designed siRNAs for Calr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26881
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Calr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Calr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-109113
CAS No.: 236095-26-4
Synonyms: GPX-150
Target:
Research Areas:
Camsirubicin (GPX-150) is a non-cardiotoxic Doxorubicin (HY-15142) analog that selectively targets topoisomerase IIβ. Camsirubicin reduces cell viability and clone formation of MDA-MB-468 breast cancer cells. Camsirubicin increases the exposure of CALR and HSP90 on the cell surface. Camsirubicin can be used for the study of breast cancer .
Cat. No.: HY-P706004
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Calr; FLJ26680; Calreticulin; CRP55; Calregulin; ERp60; CC1qR; HACBP; Calr1; Grp60; SSA; Epididymis Secretory Sperm Binding Protein Li 99n; CRT; Autoantigen Ro; RO; HEL-S-99n; Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin); CRTC; Endoplasmic Reti
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Cat. No.: HY-P72111
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Calr; FLJ26680; Calreticulin; CRP55; Calregulin; ERp60; CC1qR; HACBP; Calr1; Grp60; SSA; Epididymis Secretory Sperm Binding Protein Li 99n; CRT; Autoantigen Ro; RO; HEL-S-99n; Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin); CRTC; Endoplasmic Reti
Cat. No.: HY-P71722
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Calr; FLJ26680; Calreticulin; CRP55; Calregulin; ERp60; CC1qR; HACBP; Calr1; Grp60; SSA; Epididymis Secretory Sperm Binding Protein Li 99n; CRT; Autoantigen Ro; RO; HEL-S-99n; Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin); CRTC; Endoplasmic Reti
Species:
Source:
Cat. No.: HY-P7712
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Calr3; Calreticulin-2; Calreticulin 3; FLJ25355; CRT2; MGC26577; Calsperin; Testis Secretory Sperm-Binding Protein Li 226n; CT93; Calreticulin; Cancer/Testis Antigen 93; CMH19; Calreticulin-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
