236095-26-4
Chemical Structure
Camsirubicin
Synonym(s): GPX-150
- CAS No.: 236095-26-4
- Formula:C27H32N2O9
- Molecular Weight:528.55
IUPAC Name: (8R,10S)-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-7,9,10,12-tetrahydrotetracen-5(8H)-one
InChIKey: GNCWGPLZJLZZPI-KUIJCEFOSA-N
SMILES: OC1=C(C[C@](CCO)(O)C[C@@H]2O[C@@](O[C@@H](C)[C@H]3O)([H])C[C@@H]3N)C2=C(O)C(C4=N)=C1C(C5=CC=CC(OC)=C45)=O
Biological Activity: Camsirubicin (GPX-150) is a non-cardiotoxic Doxorubicin (HY-15142) analog that selectively targets topoisomerase IIβ. Camsirubicin reduces cell viability and clone formation of MDA-MB-468 breast cancer cells. Camsirubicin increases the exposure of CALR and HSP90 on the cell surface. Camsirubicin can be used for the study of breast cancer[1][2].
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Camsirubicin | Camsirubicin (GPX-150) is a non-cardiotoxic Doxorubicin (HY-15142) analog that selectively targets topoisomerase IIβ. Camsirubicin reduces cell viability and clone formation of MDA-MB-468 breast cancer cells. Camsirubicin increases the exposure of CALR and HSP90 on the cell surface. Camsirubicin can be used for the study of breast cancer. | |||||||||||||||||||||
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- [1]. Frank NE, et al. Comparative effects of doxorubicin and a doxorubicin analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on human topoisomerase IIβ activity and cardiac function in a chronic rabbit model. Invest New Drugs. 2016 Dec;34(6):693-700. [Content Brief]
- [2]. Xinxin Song, et al. Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers. Cancer Discov. 2020 Dec;10(12):1872-1893. [Content Brief]
Keywords
