Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
Chemotactic effect
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "Chemotactic effect" in MCE Product Catalog:
29
Category:
Neurological Disease Ketones, Aldehydes, Acids Plants Umbelliferae Disease Research Fields Endocrinology Echinacea angustifolia DC. Cancer
Target:
Cat. No.: HY-P1120
CAS No.: 187986-17-0
Synonyms: WKYMVm-amide; W-Peptide
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cat. No.: HY-P1764
CAS No.: 149146-12-3
Target:
Research Areas:
Cat. No.: HY-W017141S
CAS No.: 588732-63-2
Cat. No.: HY-W017141
CAS No.: 24683-00-9
Category:
Natural Products Other Diseases Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields
Target:
Cat. No.: HY-177270
CAS No.: 2762488-97-9
Target:
Research Areas:
CHNQD-01281, a derivative of Brefeldin A (HY-16592), is a EGFR modulator. CHNQD-01281 has strong antiproliferative activities against cancer cells (IC50: 0.079 and 0.081 μM for T24 and J82 cells, respectively). CHNQD-01281 regulates both EGFR/PI3K/AKT and EGFR/ERK pathways and mediates the chemotactic effect of chemokines on immune effector cells. CHNQD-01281 remarkably inhibits tumor growth in T24 xenograft mice model and prolongs the survival time in MB49 allogeneic mice model via inducing infiltration of cytotoxic T cells .
Cat. No.: HY-114732
CAS No.: 72332-33-3
Target:
Research Areas:
Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes .
Cat. No.: HY-174756
Target:
Research Areas:
Human CCL26 mRNA encodes the human C-C motif chemokine ligand 26 (CCL26) protein, a cytokine that displays chemotactic activity for normal peripheral blood eosinophils and basophils. CCL26 also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa.
Cat. No.: HY-174758
Target:
Research Areas:
Human CCL24 mRNA encodes the human C-C motif chemokine ligand 24 (CCL24) protein, a cytokine that displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa.
Cat. No.: HY-P11140
CAS No.: 1206554-01-9
Research Areas:
Cat. No.: HY-P1120A
CAS No.: 1313730-09-4
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cat. No.: HY-W017141R
CAS No.: 24683-00-9
Cat. No.: HY-W017141S1
CAS No.: 3028868-76-7
Cat. No.: HY-114732S
Cat. No.: HY-L132
252 compounds
Chemokines, or chemotactic cytokines, are small cytokines or signaling proteins secreted by cells. They are a component of intercellular communication, controlling the directional movement of immune cells especially leukocytes, as well as other cell types, for instance, endothelial and epithelial cells, which are essential to maintain human health and the function of the immune system.
The biological effects of chemokines are achieved by binding to chemokine receptors, which are G protein-coupled receptors found on the surface of leukocytes. Some chemokine receptors are involved in directing tumor metastasis and over-expression by certain tumors. So inhibiting the interaction between chemokine and chemokine receptors on the surface of tumor cells may be a new possible therapeutic approach. Some chemokine receptors are coreceptors for HIV entry, and related inhibitors have been approved by the FDA to treat patients with HIV. Obviously, chemokines and chemokine receptors have become new targets for studying cancer, HIV, inflammation, and other diseases.
MCE supplies a unique collection of 252 chemokine or chemokine receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on chemokine or chemokine receptors. MCE Chemokine Library is a useful tool for drug research related to cancer, AIDS, and wound therapy.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
