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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
DNA-Protein Crosslink
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "DNA-Protein Crosslink" in MCE Product Catalog:
Cat. No.: HY-W075885
CAS No.: 14913-33-8
Synonyms: trans-platinumdiamminedichloride
Cat. No.: HY-D2353
CAS No.: 756525-96-9
Cat. No.: HY-121234
CAS No.: 27098-03-9
Target:
Research Areas:
Botryodiplodin is a mycotoxin isolated from Penicillium roqueforti. Botryodiplodin inhibits the growth of some Gram-positive and Gram-negative bacteria and can also induce DNA-protein cross-links in mammalian cells, inhibiting the synthesis of DNA, RNA, and protein .
Cat. No.: HY-Y1155S
CAS No.: 51219-90-0
Cat. No.: HY-W075885R
CAS No.: 14913-33-8
Synonyms: trans-platinumdiamminedichloride (Standard)
Cat. No.: HY-13552
CAS No.: 80841-48-1
Synonyms: CI-921 isethionate; NSC 343499 isethionate
Research Areas:
Asulacrine isethionate (CI-921 isethionate) is a derivative of Amsacrine (HY-13551), a Topoisomerase II inhibitor and an anticancer agent. Asulacrine isethionate binds to DNA via intercalation, forming stable complexes with long residence times at DNA sites. Asulacrine isethionate mediates DNA breakage and DNA-protein cross-linking. Asulacrine isethionate exhibits anticancer activity against leukemia or lung cancer. Asulacrine isethionate can be used in research related to breast cancer, lung cancer, mouse solid tumors and leukemia .
Cat. No.: HY-132974
CAS No.: 165179-35-1
Synonyms: NSC-686288
Target:
Aryl Hydrocarbon Receptor Reactive Oxygen Species (ROS) DNA Alkylator/Crosslinker DNA/RNA Synthesis Caspase Apoptosis HIF/HIF Prolyl-Hydroxylase
Research Areas:
Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis). Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
